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Many types of topical hemostatic materials have been developed. One of the most current and most effective materials is TachoComb (TC), which is reabsorbed well by conversion into connective tissue. However, TC\u0027s excellent hemostatic effects are brought about by the use of hemostatic components and a framework derived from human and animal tissues. This means that TC use is associated with a risk of infectious diseases and allergic reactions. To address the above-mentioned problems with the most current hemostatic material, we devised a new hemostatic material composed of a framework of a freeze-dried gelatin sponge combined with gelatin glue, thereby creating a new topical hemostatic material made of gelatin alone. The gelatin used in the material was prepared with alkali-treatment, and the immunogenicity and activity of viruses were eliminated almost completely. The framework absorbs blood flowing out from the wound immediately, activates autologous coagulation components in the absorbed blood and promotes blood coagulation at the bleeding site. The hemostatic effects of three types of hemostatic materials were compared, namely (A) the gelatin sponge combined with gelatin glue, (B) TC and (C) gelatin glue alone, using a dog\u0027s spleen with a shaved wound surface. Consequently, combined use of the gelatin sponge and gelatin glue exhibited significantly superior hemostatic effects to the other two materials. 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[{"subitem_subject": "局所止血材", "subitem_subject_language": "ja", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ゼラチン糊", "subitem_subject_language": "ja", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ゼラチンスポンジ", "subitem_subject_language": "ja", "subitem_subject_scheme": "Other"}, {"subitem_subject": "タココンブ", "subitem_subject_language": "ja", "subitem_subject_scheme": "Other"}, {"subitem_subject": "脾臓", "subitem_subject_language": "ja", "subitem_subject_scheme": "Other"}, {"subitem_subject": "止血効果", "subitem_subject_language": "ja", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Topical hemostatic material", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "gelatin glue", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "gelatin sponge", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "TachoComb", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "spleen", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "hemostatic effect", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Gelatin sponge sheet combined with gelatin glue as new topical hemostatic materials : a preliminary report in an animal model", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Gelatin sponge sheet combined with gelatin glue as new topical hemostatic materials : a preliminary report in an animal model", "subitem_title_language": "en"}]}, "item_type_id": "1", "owner": "20", "path": ["3820", "8403"], "permalink_uri": 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Gelatin sponge sheet combined with gelatin glue as new topical hemostatic materials : a preliminary report in an animal model
https://doi.org/10.14988/pa.2017.0000013078
https://doi.org/10.14988/pa.2017.00000130787b982fad-1987-4847-9f7f-c024f5303b2c
名前 / ファイル | ライセンス | アクション |
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023054010006.pdf (330.3 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2013-05-29 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Gelatin sponge sheet combined with gelatin glue as new topical hemostatic materials : a preliminary report in an animal model | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題 | 局所止血材, ゼラチン糊, ゼラチンスポンジ, タココンブ, 脾臓, 止血効果 Topical hemostatic material, gelatin glue, gelatin sponge, TachoComb, spleen, hemostatic effect |
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資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.14988/pa.2017.0000013078 | |||||
ID登録タイプ | JaLC | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
Wang, Zhen
× Wang, Zhen× Kotani, Yutaka× Tamura, Atsushi× Kawasumi, Akari× Tsuji, Misaki× Hayashi, Maho× Ikeda, Junki× Orikasa, Taichi× Takamori, Hideki× Torii, Hiroko× Ozamoto, Yuki× Morita, Shinichiro× Tsujimoto, Hiroyuki× Hagiwara, Akeo |
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著者所属(英) | ||||||
en | ||||||
Wang, Zhen / Undergraduate Senior, Department of Medical Life System, Doshisha University | ||||||
著者所属(英) | ||||||
en | ||||||
Kotani, Yutaka / Undergraduate Senior, Department of Medical Life System, Doshisha University | ||||||
著者所属(英) | ||||||
en | ||||||
Tamura, Atsushi / Undergraduate Senior, Department of Medical Life System, Doshisha University | ||||||
著者所属(英) | ||||||
en | ||||||
Kawasumi, Akari / Undergraduate Senior, Department of Medical Life System, Doshisha University | ||||||
著者所属(英) | ||||||
en | ||||||
Tsuji, Misaki / Undergraduate Senior, Department of Medical Life System, Doshisha University | ||||||
著者所属(英) | ||||||
en | ||||||
Hayashi, Maho / Undergraduate Senior, Department of Medical Life System, Doshisha University | ||||||
著者所属(英) | ||||||
en | ||||||
Ikeda, Junki / Department of Medical Life System, Doshisha University | ||||||
著者所属(英) | ||||||
en | ||||||
Orikasa, Taichi / Department of Medical Life System, Doshisha University | ||||||
著者所属(英) | ||||||
en | ||||||
Takamori, Hideki / Research and Development Department, Gunze Ltd | ||||||
著者所属(英) | ||||||
en | ||||||
Torii, Hiroko / Department of Medical Life System, Doshisha University / Kusatsu General Hospital | ||||||
著者所属(英) | ||||||
en | ||||||
Ozamoto, Yuki / Kusatsu General Hospital | ||||||
著者所属(英) | ||||||
en | ||||||
Morita, Shinichiro / Research and Development Department, Gunze Ltd | ||||||
著者所属(英) | ||||||
en | ||||||
Tsujimoto, Hiroyuki / Department of Medical Life System, Doshisha University | ||||||
著者所属(英) | ||||||
en | ||||||
Hagiwara, Akeo / Department of Medical Life System, Doshisha University | ||||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 手術中の制御困難な出血は死亡率増加や医療費の高額化をもたらすため、術中止血は重要な課題である。そのため、多くの局所止血材が開発されている。このうちで、タココンブ(TC)は最も使用頻度が高く効果的な局所止血材の一つである。しかし、TCの優れた止血効果はヒト血液製剤と動物組織由来の止血成分を構成要素として使用されていることによる。これはTCの使用により感染症やアレルギー反応のリスクが高くなる問題を引き起こす。この問題を解決するために、アルカリ処理によりゼラチンのウイルスや抗原性構造部位ほぼ完全に排除されることに着目し、筆者らは構成要素としてアルカリ処理ゼラチンのみを使用しこれを凍結乾燥してゼラチンスポンジ作成し、これとゼラチン糊とを組み合わせた新規の止血材を考案した。スポンジ構造が傷口からの流出血液を速やかに吸収してゼラチンと粘性ゲルを形成し、同時に血中凝固成分が直ちに活性化され、その結果、出血部位で急速に血餅形成が促進される。更にゼラチン糊が血餅を含む粘性ゲルを出血部位に強固に糊着させる。本実験では(A)ゼラチンスポンジとゼラチン糊との組み合わせ、(B)タココンブ単独、(C)ゼラチン糊単独の3種類の止血材について、犬の脾臓表面を損傷させた実験モデルを用いて止血効果を比較した。その結果、ゼラチンスポンジとゼラチン糊の併用は、他の2つの材料に比較して有意に優れた止血効果を示した。結論として、ゼラチンスポンジとゼラチン糊の組み合わせは、その優れた止血効果に加えて、感染症やアレルギー反応のリスクが極めて低い利点を持つ、有用な局所止血材であることが明らかになった。 | |||||
言語 | ja | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Hemostasis is a key issue in surgery because uncontrolled surgical bleeding is associated with increased mortality rates and higher costs. Many types of topical hemostatic materials have been developed. One of the most current and most effective materials is TachoComb (TC), which is reabsorbed well by conversion into connective tissue. However, TC's excellent hemostatic effects are brought about by the use of hemostatic components and a framework derived from human and animal tissues. This means that TC use is associated with a risk of infectious diseases and allergic reactions. To address the above-mentioned problems with the most current hemostatic material, we devised a new hemostatic material composed of a framework of a freeze-dried gelatin sponge combined with gelatin glue, thereby creating a new topical hemostatic material made of gelatin alone. The gelatin used in the material was prepared with alkali-treatment, and the immunogenicity and activity of viruses were eliminated almost completely. The framework absorbs blood flowing out from the wound immediately, activates autologous coagulation components in the absorbed blood and promotes blood coagulation at the bleeding site. The hemostatic effects of three types of hemostatic materials were compared, namely (A) the gelatin sponge combined with gelatin glue, (B) TC and (C) gelatin glue alone, using a dog's spleen with a shaved wound surface. Consequently, combined use of the gelatin sponge and gelatin glue exhibited significantly superior hemostatic effects to the other two materials. In the conclusion, the combination of a gelatin sponge sheet and gelatin glue is useful as a topical hemostatic material due to its superior hemostatic effects and extremely low risk of infectious diseases and allergic reactions. | |||||
言語 | en | |||||
書誌情報 |
ja : 同志社大学理工学研究報告 en : The Science and Engineering Review of Doshisha University 巻 54, 号 1, p. 36-40, 発行日 2013-04-30 |
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出版者 | ||||||
言語 | ja | |||||
出版者 | 同志社大学理工学研究所 | |||||
出版者(英) | ||||||
言語 | en | |||||
出版者 | Science and Engineering Research Institute of Doshisha University | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 00368172 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00165868 | |||||
権利者情報 | ||||||
権利者名 | 同志社大学理工学研究所 | |||||
言語 | ja | |||||
権利者名 | Science and Engineering Research Institute of Doshisha University | |||||
言語 | en | |||||
関連サイト | ||||||
関連タイプ | isFormatOf | |||||
識別子タイプ | URI | |||||
関連識別子 | https://doors.doshisha.ac.jp/opac/opac_link/bibid/SB00960326/?lang=0 | |||||
言語 | ja | |||||
関連名称 | 掲載刊行物所蔵情報へのリンク / Link to Contents | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
日本十進分類法 | ||||||
主題 | 464.26 |