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Chitosan sponge has a better local hemostatic effect than alginate sponge in animal experiment
https://doi.org/10.14988/pa.2017.0000012777
https://doi.org/10.14988/pa.2017.00000127772fc0e776-cc5e-43be-a35e-ce38ad352aa4
名前 / ファイル | ライセンス | アクション |
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023053010008.pdf (5.0 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||||||||
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公開日 | 2012-06-12 | |||||||||||
タイトル | ||||||||||||
言語 | en | |||||||||||
タイトル | Chitosan sponge has a better local hemostatic effect than alginate sponge in animal experiment | |||||||||||
言語 | ||||||||||||
言語 | eng | |||||||||||
キーワード | ||||||||||||
主題 | 止血材料, キトサンスポンジ, アルギン酸スポンジ, 止血効果, 組織接着強度 hemostatic material, chitosan sponge, alginate sponge, hemostatic effect, tissue-adhesion intensity |
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資源タイプ | ||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
資源タイプ | departmental bulletin paper | |||||||||||
ID登録 | ||||||||||||
ID登録 | 10.14988/pa.2017.0000012777 | |||||||||||
ID登録タイプ | JaLC | |||||||||||
アクセス権 | ||||||||||||
アクセス権 | open access | |||||||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
その他(別言語等)のタイトル | ||||||||||||
その他のタイトル | 動物実験においてキトサンスポンジはアルギン酸スポンジよりも優れた局所止血効果があることを示す | |||||||||||
言語 | ja | |||||||||||
その他(別言語等)のタイトル | ||||||||||||
その他のタイトル | ドウブツ ジッケン ニオイテ キトサン スポンジ ワ アルギンサン スポンジ ヨリ モ スグレタ キョクショ シケツ コウカ ガ アル コト オ シメス | |||||||||||
言語 | ja-Kana | |||||||||||
著者 |
池田, 潤基
× 池田, 潤基× 折笠, 太一× 丹澤, あゆみ× 的場, 麻理× 岩目, 芳純× 吉田, 千子× 鳥井, 裕子× 小座本, 雄軌× 橋本, 歩× 辻本, 洋行
WEKO
16525
× 萩原, 明郎 |
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著者所属(英) | ||||||||||||
en | ||||||||||||
Ikeda, Junki / Undergraduate Senior, Department of Medical Life System, Doshisha University | ||||||||||||
著者所属(英) | ||||||||||||
en | ||||||||||||
Orikasa, Taichi / Undergraduate Senior, Department of Medical Life System, Doshisha University | ||||||||||||
著者所属(英) | ||||||||||||
en | ||||||||||||
Tanzawa, Ayumi / Undergraduate Senior, Department of Medical Life System, Doshisha University | ||||||||||||
著者所属(英) | ||||||||||||
en | ||||||||||||
Matoba, Mari / Undergraduate Senior, Department of Medical Life System, Doshisha University | ||||||||||||
著者所属(英) | ||||||||||||
en | ||||||||||||
Iwame, Yoshizumi / Undergraduate Senior, Department of Medical Life System, Doshisha University | ||||||||||||
著者所属(英) | ||||||||||||
en | ||||||||||||
Yoshida, Chiko / Undergraduate sophomore, Department of Medical Life System, Doshisha University | ||||||||||||
著者所属(英) | ||||||||||||
en | ||||||||||||
Torii, Hiroko / Graduate Student, Department of Medical Life System, Doshisha University | ||||||||||||
著者所属(英) | ||||||||||||
en | ||||||||||||
Ozamoto, Yuki / Department of Kusatsu General Hospital | ||||||||||||
著者所属(英) | ||||||||||||
en | ||||||||||||
Hashimoto, Ayumi / Research fellow, Department of Medical Life System, Doshisha University | ||||||||||||
著者所属(英) | ||||||||||||
en | ||||||||||||
Tsujimoto, Hiroyuki / Department of Medical Life System, Doshisha University | ||||||||||||
著者所属(英) | ||||||||||||
en | ||||||||||||
Hagiwara, Akeo / Department of Medical Life System, Doshisha University | ||||||||||||
抄録 | ||||||||||||
内容記述タイプ | Abstract | |||||||||||
内容記述 | コラーゲン製材とフィブリン製材は、幅広く使用されている局所止血材料である。しかし、コラーゲン製材は局所感染を促進したり、異種動物由来の蛋白を含むゆえのアレルギー反応を引き起こす傾向がある。フィブリン製材は人間由来の物質を含んでいるので、ウイルス感染の危険性を伴う。そこで当研究室は、キトサンが異種動物や人間由来ではなく蟹由来であることに注目して、上記の問題をほとんど持たない新規局所止血材料として“キトサンスポンジ"を開発した。本実験では、凍結乾燥法によりキトサンスポンジを作製し、別の局所止血材料であるアルギン酸から作製したスポンジ製材との比較において、組織接着強度と止血効果を検討した。最大せん断応力により評価した組織接着強度は、キトサン群ではアルギン酸群に比較して有意に大であった。ラットの腸間膜からの出血量で評価した止血効果は、キトサン群ではアルギン酸群に比較して有意に優れていた。これらの結果は、キトサンスポンジが新規局所止血材料として有用であることを示唆していると考えられた。 | |||||||||||
言語 | ja | |||||||||||
抄録 | ||||||||||||
内容記述タイプ | Abstract | |||||||||||
内容記述 | Collagen-preparation and fibrin glue are widely used local hemostatic materials. Collagen-preparation, however, can promote local infections, and tends to cause allergic reactions, since it contains proteins from different kinds of animals. Fibrin glue is associated with risks of viral infections, because it contains materials from human beings. Therefore, this laboratory developed the “chitosan sponge", as a novel local hemostatic material with few such problems, because chitosan is derived from neither different kinds of animals nor humans but from crabs. In the experiment, chitosan sponge was made by a freeze-drying method, and was evaluated in for tissue-adhesion intensity and hemostatic effects, in comparison to sponge of alginate, another hemostatic material. The tissue-adhesion intensity of these materials was evaluated by their maximal shear stress. The maximal shear stress in the chitosan group was significantly large in comparison to that in the alginate group. The hemostatic effect was indicated with blood amount bleeding from the mesentery in rats. There was significantly little bleeding in the chitosan group in comparison to that in the alginate group. These results suggest that the chitosan sponge can be useful as a novel local hemostatic material. | |||||||||||
言語 | en | |||||||||||
書誌情報 |
ja : 同志社大学理工学研究報告 en : The Science and Engineering Review of Doshisha University 巻 53, 号 1, p. 49-53, 発行日 2012-04-30 |
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出版者 | ||||||||||||
言語 | ja | |||||||||||
出版者 | 同志社大学理工学研究所 | |||||||||||
出版者(英) | ||||||||||||
言語 | en | |||||||||||
出版者 | Science and Engineering Research Institute of Doshisha University | |||||||||||
ISSN | ||||||||||||
収録物識別子タイプ | PISSN | |||||||||||
収録物識別子 | 00368172 | |||||||||||
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収録物識別子タイプ | NCID | |||||||||||
収録物識別子 | AN00165868 | |||||||||||
権利者情報 | ||||||||||||
権利者名 | 同志社大学理工学研究所 | |||||||||||
言語 | ja | |||||||||||
権利者名 | Science and Engineering Research Institute of Doshisha University | |||||||||||
言語 | en | |||||||||||
関連サイト | ||||||||||||
関連タイプ | isFormatOf | |||||||||||
識別子タイプ | URI | |||||||||||
関連識別子 | https://doors.doshisha.ac.jp/opac/opac_link/bibid/SB00960326/?lang=0 | |||||||||||
言語 | ja | |||||||||||
関連名称 | 掲載刊行物所蔵情報へのリンク / Link to Contents | |||||||||||
フォーマット | ||||||||||||
内容記述タイプ | Other | |||||||||||
内容記述 | application/pdf | |||||||||||
出版タイプ | ||||||||||||
出版タイプ | VoR | |||||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
日本十進分類法 | ||||||||||||
主題 | 499.6 |