{"created":"2023-07-27T07:53:44.522719+00:00","id":29597,"links":{},"metadata":{"_buckets":{"deposit":"77371dcd-3bbe-4753-bfd0-8aaf421266f5"},"_deposit":{"created_by":21,"id":"29597","owners":[21],"pid":{"revision_id":0,"type":"depid","value":"29597"},"status":"published"},"_oai":{"id":"oai:doshisha.repo.nii.ac.jp:00029597","sets":["4151:8699:4203:4204","4251:7687:7688:8785:7689"]},"author_link":["30761","30936"],"item_1693813220986":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1694497428290":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(理学)","subitem_degreename_language":"ja"}]},"item_1694497507610":{"attribute_name":"学位名（英）","attribute_value_mlt":[{"subitem_degreename":"Doctor of Philosophy in Science","subitem_degreename_language":"en"}]},"item_1694497573527":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"同志社大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Doshisha University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"34310","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_3_alternative_title_2":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"神経幹細胞における細胞内カルシウム変動の役割","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"シンケイ カンサイボウ ニオケル サイボウナイ カルシウム ヘンドウ ノ ヤクワリ","subitem_alternative_title_language":"ja-Kana"}]},"item_3_contributor_35":{"attribute_name":"指導教員","attribute_value_mlt":[{"contributorNames":[{"contributorName":"Motoyama, Jun","lang":"en"},{"contributorName":"元山, 純","lang":"ja"},{"contributorName":"モトヤマ, ジュン","lang":"ja-Kana"}],"familyNames":[{"familyName":"Motoyama","familyNameLang":"en"},{"familyName":"元山","familyNameLang":"ja"},{"familyName":"モトヤマ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Jun","givenNameLang":"en"},{"givenName":"純","givenNameLang":"ja"},{"givenName":"ジュン","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"30761","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000070321825","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000070321825"},{"nameIdentifier":"70321825","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=70321825"}]}]},"item_3_date_granted_27":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2023-03-22"}]},"item_3_description_12":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"神経幹細胞(NPC)は神経細胞に分化することができ、脳の発達に重要である。しかし、NPCの分化についてのメカニズムはまだよくわかっていない。カルシウム (Ca2+) イメージングを用いて胎児脳に観察される細胞内Ca2+変動を調べた。NPCの細胞内Ca2+変動における間欠的細胞内Ca2+トランジェントの開始が神経細胞の分化と相関することを見出した。さらに、NPCの細胞内Ca2+変動はT型Ca2+チャネルによって仲介され、このCa2+チャネルの遮断は神経分化を阻害することを見出した。したがって、NPCの細胞内Ca2+変動は神経分化に必要である。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Neural progenitor cell (NPC) can differentiate into neuron and is important for brain development. However, mechanisms controlling the differentiation of NPCs are not well understood. Using calcium (Ca2+) imaging, we examined intracellular Ca2+ fluctuation that is frequently observed during embryonic development. We found that the onset of the intermittent intracellular Ca2+ transients in NPC intracellular Ca2+ fluctuation is correlated to NPC differentiation toward neurons. Furthermore, the intracellular Ca2+ fluctuation in NPC was mediated by the T-type Ca2+ channel and blockage of this Ca2+ channel inhibited neuronal differentiation. Thus, intracellular Ca2+ fluctuations in NPC are required for neural differentiation.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_3_description_18":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_3_dissertation_number_28":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第1302号"}]},"item_3_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.14988/0000029597","subitem_identifier_reg_type":"JaLC"}]},"item_3_relation_16":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"BD0519220X","subitem_relation_type_select":"NCID"}}]},"item_3_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"掲載刊行物所蔵情報へのリンク ／ Link to Contents"}],"subitem_relation_type":"isFormatOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doors.doshisha.ac.jp/opac/opac_link/bibid/BB13225161/?lang=0","subitem_relation_type_select":"URI"}}]},"item_3_text_8":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"脳科学研究科"}]},"item_3_text_9":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Graduate School of Brain Science"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Rhaditya, Putu Adi Andhika","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-04-24"}],"displaytype":"detail","filename":"k1302.pdf","filesize":[{"value":"396.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"要旨/abstaract","objectType":"abstract","url":"https://doshisha.repo.nii.ac.jp/record/29597/files/k1302.pdf"},"version_id":"495308ec-c78b-4655-875f-1e8dda5767c3"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-04-24"}],"displaytype":"detail","filename":"zk1302.pdf","filesize":[{"value":"12.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://doshisha.repo.nii.ac.jp/record/29597/files/zk1302.pdf"},"version_id":"11dad3e4-148a-4370-a4a1-99e9f2e95e34"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"カルシウムシグナリング","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"神経幹細胞の分化","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Calcium signaling","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Neural progenitor cell differentiation","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"The role of [Ca2+]i fluctuation in cortical neural progenitor cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The role of [Ca2+]i fluctuation in cortical neural progenitor cells","subitem_title_language":"en"}]},"item_type_id":"3","owner":"21","path":["4204","7689"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-04-24"},"publish_date":"2023-04-24","publish_status":"0","recid":"29597","relation_version_is_last":true,"title":["The role of [Ca2+]i fluctuation in cortical neural progenitor cells"],"weko_creator_id":"21","weko_shared_id":-1},"updated":"2024-02-05T07:31:59.383405+00:00"}