{"created":"2023-07-27T07:53:35.032637+00:00","id":29402,"links":{},"metadata":{"_buckets":{"deposit":"6510e2d9-de13-445c-8209-570d4fc41754"},"_deposit":{"created_by":21,"id":"29402","owners":[21],"pid":{"revision_id":0,"type":"depid","value":"29402"},"status":"published"},"_oai":{"id":"oai:doshisha.repo.nii.ac.jp:00029402","sets":["4251:8138:8139:8140:9229","8:3372:3847:9228"]},"author_link":["30680","30681","30684","30685"],"item_1693811493084":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1694490770713":{"attribute_name":"権利者情報","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"DA18202107","nameIdentifierScheme":"AID"}],"rightHolderNames":[{"rightHolderLanguage":"ja","rightHolderName":"同志社大学ハリス理化学研究所"},{"rightHolderLanguage":"en","rightHolderName":"Harris Science Research Institute of Doshisha University"}]}]},"item_1_alternative_title_2":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"インテリジェントな人工亜鉛フィンガータンパク質の創製と生物学的応用","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"インテリジェントナ ジンコウ アエン フィンガー タンパクシツ ノ ソウセイ ト セイブツガクテキ オウヨウ","subitem_alternative_title_language":"ja-Kana"}]},"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-01-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"234","bibliographicPageStart":"227","bibliographicVolumeNumber":"63","bibliographic_titles":[{"bibliographic_title":"同志社大学ハリス理化学研究報告","bibliographic_titleLang":"ja"},{"bibliographic_title":"The Harris science review of Doshisha University","bibliographic_titleLang":"en"}]}]},"item_1_description_12":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ジンクフィンガータンパク質は，ヒトプロテオーム中に豊富に存在し，様々な機能に関与している．ジンクフィンガータンパク質の生物学的重要性，その機能向上や生物学的応用を目的として，多くの人工ジンクフィンガータンパク質が創製されてきた．ここでは，人工ジンクフィンガータンパク質の再設計と応用に関する先行研究を，我々の実験結果を中心にレビューする．また，人工ジンクフィンガータンパク質の生物学的応用の可能性についても議論する．このレビューは，様々な疾患に対する新しい治療法を提供する可能性のある人工ジンクフィンガータンパク質の分野で研究者に関連情報を提供するものである．","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Zinc finger proteins are abundant in the human proteome and are involved in various functions. Given the biological importance of zinc finger proteins, many artificial zinc finger proteins have been created to improve their function and biological applications. Here, we review previous studies on the redesign and application of artificial zinc finger proteins, focusing on our experimental results. We also discuss the potential biological applications of artificial zinc finger proteins. This review will provide relevant information to researchers working in or interested in the field of engineered zinc finger proteins, which may provide new therapeutic approaches to various diseases.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_1_description_25":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_1_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.14988/00029401","subitem_identifier_reg_type":"JaLC"}]},"item_1_publisher_15":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"同志社大学ハリス理化学研究所","subitem_publisher_language":"ja"}]},"item_1_publisher_16":{"attribute_name":"出版者（英）","attribute_value_mlt":[{"subitem_publisher":"Harris Science Research Institute of Doshisha University","subitem_publisher_language":"en"}]},"item_1_relation_24":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"掲載刊行物所蔵情報へのリンク ／ Link to Contents"}],"subitem_relation_type":"isFormatOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doors.doshisha.ac.jp/opac/opac_link/bibid/SB12902196/?lang=0","subitem_relation_type_select":"URI"}}]},"item_1_source_id_17":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"21895937","subitem_source_identifier_type":"PISSN"}]},"item_1_source_id_19":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12716107","subitem_source_identifier_type":"NCID"}]},"item_1_subject_27":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"491.42","subitem_subject_scheme":"NDC"}]},"item_1_text_8":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"根木, 滋 / 同志社女子大学薬学部 / 同志社大学ナノ・バイオサイエンス研究センター研究員"},{"subitem_text_language":"ja","subitem_text_value":"羽森, 真美 / 同志社女子大学薬学部 / 同志社大学ナノ・バイオサイエンス研究センター研究員"},{"subitem_text_language":"ja","subitem_text_value":"北岸, 宏亮 / 同志社大学理工学部 / 同志社大学ナノ・バイオサイエンス研究センター研究員"},{"subitem_text_language":"ja","subitem_text_value":"杉浦, 幸雄 / 同志社女子大学薬学部 / 同志社大学ナノ・バイオサイエンス研究センター研究員"}]},"item_1_text_9":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Negi, Shigeru / Faculty of Pharmaceutical Science, Doshisha Women's College of Liberal Arts"},{"subitem_text_language":"en","subitem_text_value":"Hamori, Mami / Faculty of Pharmaceutical Science, Doshisha Women's College of Liberal Arts"},{"subitem_text_language":"en","subitem_text_value":"Kitagishi, Hiroaki / Department of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University"},{"subitem_text_language":"en","subitem_text_value":"Sugiura, Yukio / Faculty of Pharmaceutical Science, Doshisha Women's College of Liberal Arts"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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Yukio","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"30685","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000040025698","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000040025698"},{"nameIdentifier":"40025698","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40025698"},{"nameIdentifier":"DA05906311","nameIdentifierScheme":"AID","nameIdentifierURI":"https://ci.nii.ac.jp/author/DA05906311"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-02-13"}],"displaytype":"detail","filename":"023063040007.pdf","filesize":[{"value":"2.8 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finger","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Redesign","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Metalloprotein","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Zinc finger nuclease","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Creation and biological application of intelligent zinc finger proteins","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Creation and biological application of intelligent zinc finger 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