{"created":"2023-07-27T07:53:26.907232+00:00","id":29238,"links":{},"metadata":{"_buckets":{"deposit":"51ae2c35-a24e-492a-853a-6426a067070a"},"_deposit":{"created_by":1,"id":"29238","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"29238"},"status":"published"},"_oai":{"id":"oai:doshisha.repo.nii.ac.jp:00029238","sets":["4151:8699:4190:4192","4251:7209:7210:8775:7212"]},"author_link":["30779"],"control_number":"29238","item_1693813220986":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1694497428290":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(理学)","subitem_degreename_language":"ja"}]},"item_1694497507610":{"attribute_name":"学位名（英）","attribute_value_mlt":[{"subitem_degreename":"Doctor of Philosophy in Science","subitem_degreename_language":"en"}]},"item_1694497573527":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"同志社大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Doshisha University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"34310","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_3_alternative_title_2":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"エンドペルオキシドからの一重項酸素は、HaCaTケラチノサイトにおける細胞内活性酸素産生を誘導する","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"エンドペルオキシド カラノ イチジュウコウ サンソ ワ HaCaT ケラチノサイト ニオケル サイボウナイ カッセイ サンソ サンセイ オ ユウドウ スル","subitem_alternative_title_language":"ja-Kana"},{"subitem_alternative_title":"エンドペルオキシドからの一重項酸素はHaCaTケラチノサイトにおける細胞内活性酸素産生を誘導する","subitem_alternative_title_language":"ja"}]},"item_3_contributor_35":{"attribute_name":"指導教員","attribute_value_mlt":[{"contributorNames":[{"contributorName":"市川, 寛","lang":"ja"}]}]},"item_3_date_granted_27":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2022-09-17"}]},"item_3_description_12":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究は、エンドペルオキシド（熱分解により一重項酸素を定量的に放出する試薬）でHaCaTケラチノサイトを刺激することにより、細胞内で二次活性酸素種（ROS）が放出される効果を調べることに主眼を置いている。この現象が起こるかどうか、ひいてはどのように起こるかを理解するために、特定のROS阻害剤および/または酵素（NOX）およびPAF受容体阻害剤を使用した。二次的活性酸素、特にスーパーオキシド、過酸化水素、一重項酸素の放出を確認するために、化学発光およびROS感受性アッセイが採用された。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"This research is focused on studying the effects of stimulating HaCaT keratinocytes with endoperoxide (a reagent that quantitatively releases singlet oxygen by thermal decomposition) on the release of secondary reactive oxygen species (ROS) intracellularly. To understand whether this phenomenon occurs, and consequently how it occurs, specific ROS inhibitors and/ or enzyme (NOX) and PAF receptor inhibitors were used. Chemiluminescence and ROS sensitive assays were employed to confirm the release of secondary ROS, particularly superoxide, hydrogen peroxide and singlet oxygen.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_3_description_18":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_3_dissertation_number_28":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第1252号"}]},"item_3_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.14988/0000029238","subitem_identifier_reg_type":"JaLC"}]},"item_3_relation_16":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"BD04087006","subitem_relation_type_select":"NCID"}}]},"item_3_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"掲載刊行物所蔵情報へのリンク ／ Link to Contents"}],"subitem_relation_type":"isFormatOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doors.doshisha.ac.jp/opac/opac_link/bibid/BB13219766/?lang=0","subitem_relation_type_select":"URI"}}]},"item_3_text_8":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"生命医科学研究科"}]},"item_3_text_9":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Graduate School of Life and Medical Sciences"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Elshafei, Maryam Emad","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"30779","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1410293943122708224","nameIdentifierScheme":"CiNii Research","nameIdentifierURI":"https://cir.nii.ac.jp/crid/1410293943122708224"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-10-20"}],"displaytype":"detail","filename":"k1252.pdf","filesize":[{"value":"364.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"要旨/abstaract","objectType":"abstract","url":"https://doshisha.repo.nii.ac.jp/record/29238/files/k1252.pdf"},"version_id":"9409143e-996b-49d0-8de7-94786ee76440"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-10-20"}],"displaytype":"detail","filename":"zk1252.pdf","filesize":[{"value":"1.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://doshisha.repo.nii.ac.jp/record/29238/files/zk1252.pdf"},"version_id":"f0ccad9a-0e16-4dc1-b260-8c3c51b04484"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"一重項酸素","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"エンドペルオキシド","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Singlet oxygen","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Endoperoxide","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Singlet oxygen from endoperoxide initiates an intracellular ROS release in HaCaT keratinocytes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Singlet oxygen from endoperoxide initiates an intracellular ROS release in HaCaT keratinocytes","subitem_title_language":"en"}]},"item_type_id":"3","owner":"1","path":["4192","7212"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-10-20"},"publish_date":"2022-10-20","publish_status":"0","recid":"29238","relation_version_is_last":true,"title":["Singlet oxygen from endoperoxide initiates an intracellular ROS release in HaCaT keratinocytes"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-12-15T01:53:22.913980+00:00"}