{"created":"2023-07-27T07:53:08.840896+00:00","id":28866,"links":{},"metadata":{"_buckets":{"deposit":"37f0ae92-4921-40cc-87a3-57ad7dd432c6"},"_deposit":{"created_by":21,"id":"28866","owners":[21],"pid":{"revision_id":0,"type":"depid","value":"28866"},"status":"published"},"_oai":{"id":"oai:doshisha.repo.nii.ac.jp:00028866","sets":["4151:8699:4190:4191","4251:7209:7210:8775:7211"]},"author_link":["15426","30601"],"item_1693813220986":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1694497428290":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(工学)","subitem_degreename_language":"ja"}]},"item_1694497507610":{"attribute_name":"学位名（英）","attribute_value_mlt":[{"subitem_degreename":"Doctor of Philosophy in Engineering","subitem_degreename_language":"en"}]},"item_1694497573527":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"同志社大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Doshisha University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"34310","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_3_alternative_title_2":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"時系列の遺伝子発現プロファイルを使用した治療効果の予測方法","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"ジケイレツ ノ イデンシ ハツゲン プロファイル オ シヨウ シタ チリョウ コウカ ノ ヨソク ホウホウ","subitem_alternative_title_language":"ja-Kana"}]},"item_3_contributor_35":{"attribute_name":"指導教員","attribute_value_mlt":[{"contributorNames":[{"contributorName":"Hiroyasu, Tomoyuki","lang":"en"},{"contributorName":"廣安, 知之","lang":"ja"},{"contributorName":"ヒロヤス, トモユキ","lang":"ja-Kana"}],"familyNames":[{"familyName":"Hiroyasu","familyNameLang":"en"},{"familyName":"廣安","familyNameLang":"ja"},{"familyName":"ヒロヤス","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Tomoyuki","givenNameLang":"en"},{"givenName":"知之","givenNameLang":"ja"},{"givenName":"トモユキ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"15426","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000020298144","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000020298144"},{"nameIdentifier":"20298144","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20298144"},{"nameIdentifier":"0000-0003-0730-7905","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0003-0730-7905"}]}]},"item_3_date_granted_27":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2022-03-22"}]},"item_3_description_12":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"バイオマーカーはある特定の疾病や体質に関与する生体内分子のことであり，個別化医療の実現に貢献する．時系列の遺伝子発現プロファイルはバイオマーカーの探索に有用であるが，サンプルサイズに対して遺伝子数が多い，遺伝子間の多重共線性，時系列の複雑さなどの課題があった．本研究では，これらの課題に対応した時系列の遺伝子プロファイルを用いたバイオマーカーの探索手法を提案し，その有効性を示した．","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Biomarkers contribute to designing the therapy. Time-course gene expression profiles were useful for biomarker discovery. However, biomarker discovery using time-course gene expression profiles suffered from three difficulties, including (1) high dimensional data with small sample size and a large number of genes, (2) multi-collinearity among genes, and (3) complexity of time-course. To solve these problems, expanding elastic net for consistent differentiation (eENCD) and consolidating probabilities of multiple time points (CPMTP) as new biomarker discovery methods using time-course gene expression profiles, were proposed and evaluated.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_3_description_18":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_3_dissertation_number_28":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第1220号"}]},"item_3_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.14988/00028858","subitem_identifier_reg_type":"JaLC"}]},"item_3_relation_16":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"BD01726619","subitem_relation_type_select":"NCID"}}]},"item_3_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"掲載刊行物所蔵情報へのリンク ／ Link to Contents"}],"subitem_relation_type":"isFormatOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doors.doshisha.ac.jp/opac/opac_link/bibid/BB13207253/?lang=0","subitem_relation_type_select":"URI"}}]},"item_3_text_8":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"生命医科学研究科"}]},"item_3_text_9":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Graduate School of Life and Medical Sciences"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"福島, 亜梨花","creatorNameLang":"ja"},{"creatorName":"フクシマ, アリカ","creatorNameLang":"ja-Kana"},{"creatorName":"Fukushima, Arika","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-04-18"}],"displaytype":"detail","filename":"k1220.pdf","filesize":[{"value":"478.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"要旨/abstaract","objectType":"abstract","url":"https://doshisha.repo.nii.ac.jp/record/28866/files/k1220.pdf"},"version_id":"38eec638-4574-4051-9bf8-8cbbf6672eec"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-02"}],"displaytype":"detail","filename":"zk1220.pdf","filesize":[{"value":"2.4 MB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"zk1220.pdf","objectType":"fulltext","url":"https://doshisha.repo.nii.ac.jp/record/28866/files/zk1220.pdf"},"version_id":"63433da4-2345-44f3-8f25-fc2121c2eec4"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"時系列","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子発現プロファイル","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"治療効果","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"予測","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Time-course","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Gene expression profiles","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Therapeutic response","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Prediction","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Prediction method for therapeutic response at multiple time points of gene expression profiles","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Prediction method for therapeutic response at multiple time points of gene expression profiles","subitem_title_language":"en"}]},"item_type_id":"3","owner":"21","path":["4191","7211"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-04-18"},"publish_date":"2022-04-18","publish_status":"0","recid":"28866","relation_version_is_last":true,"title":["Prediction method for therapeutic response at multiple time points of gene expression profiles"],"weko_creator_id":"21","weko_shared_id":-1},"updated":"2024-02-29T06:13:26.346493+00:00"}