{"created":"2023-07-27T07:52:51.146724+00:00","id":28496,"links":{},"metadata":{"_buckets":{"deposit":"d50c17e0-9b6d-42f3-a1ae-6bf47dd220e8"},"_deposit":{"created_by":20,"id":"28496","owners":[20],"pid":{"revision_id":0,"type":"depid","value":"28496"},"status":"published"},"_oai":{"id":"oai:doshisha.repo.nii.ac.jp:00028496","sets":["4151:8699:4190:4192","4251:7209:7210:8775:7212"]},"author_link":["30443"],"item_1693813220986":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1694497428290":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(理学)","subitem_degreename_language":"ja"}]},"item_1694497507610":{"attribute_name":"学位名（英）","attribute_value_mlt":[{"subitem_degreename":"Doctor of Philosophy in Science","subitem_degreename_language":"en"}]},"item_1694497573527":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"同志社大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Doshisha University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"34310","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_3_alternative_title_2":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"小脳におけるアミロイド沈着防御機構の解明","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"ショウノウ ニオケル アミロイド チンチャク ボウギョ キコウ ノ カイメイ","subitem_alternative_title_language":"ja-Kana"}]},"item_3_date_granted_27":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2021-09-18"}]},"item_3_description_12":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aβ is still best known as a molecule to cause AD through accumulation and deposition within the frontal cortex and hippocampus in the brain that depends on rate of synthesis and clearance of Aβ. Aβ clearance or degradation rather than its synthesis have been found to be more critical in accumulation of Aβ. Therefore, Aβ clearance pathways have been emerged as a new therapeutic target for AD treatment. In the present study indicate that diffusion mediated clearance and drainage from CBL is responsible for less Aβ in CBL than that of CTX. Application of this defense mechanism to CTX would prevent from AD. Although it is not fully clear Aβ about clearance, this finding will draw attention of AD scientist to find out the best possible mechanism after more investigation. Once it may possible, it would be applicable for not only AD pathogenesis but also prevention and cure of AD.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_3_description_18":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_3_dissertation_number_28":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第1187号"}]},"item_3_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.14988/00028488","subitem_identifier_reg_type":"JaLC"}]},"item_3_relation_16":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"BC17102637","subitem_relation_type_select":"NCID"}}]},"item_3_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"掲載刊行物所蔵情報へのリンク ／ Link to Contents"}],"subitem_relation_type":"isFormatOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doors.doshisha.ac.jp/opac/opac_link/bibid/BB13194574/?lang=0","subitem_relation_type_select":"URI"}}]},"item_3_text_8":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"生命医科学研究科"}]},"item_3_text_9":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Graduate School of Life and Medical Sciences"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Alam, Shahnur Md","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-10-04"}],"displaytype":"detail","filename":"k1187.pdf","filesize":[{"value":"288.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"要旨/abstaract","objectType":"abstract","url":"https://doshisha.repo.nii.ac.jp/record/28496/files/k1187.pdf"},"version_id":"2456e3ec-a311-4044-a31c-0d627d11f166"},{"accessrole":"open_access","displaytype":"detail","filename":"zk1187.pdf","filesize":[{"value":"2.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://doshisha.repo.nii.ac.jp/record/28496/files/zk1187.pdf"},"version_id":"06260b39-a048-4059-8342-31f9e02f7a29"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"A potential defense mechanism against amyloid deposition in cerebellum","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A potential defense mechanism against amyloid deposition in cerebellum","subitem_title_language":"en"}]},"item_type_id":"3","owner":"20","path":["4192","7212"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-10-04"},"publish_date":"2021-10-04","publish_status":"0","recid":"28496","relation_version_is_last":true,"title":["A potential defense mechanism against amyloid deposition in cerebellum"],"weko_creator_id":"20","weko_shared_id":-1},"updated":"2023-12-20T07:02:29.060597+00:00"}