{"created":"2023-07-27T07:52:11.298576+00:00","id":27643,"links":{},"metadata":{"_buckets":{"deposit":"d8519065-6945-4d9e-9013-c9f42cef7480"},"_deposit":{"created_by":20,"id":"27643","owners":[20],"pid":{"revision_id":0,"type":"depid","value":"27643"},"status":"published"},"_oai":{"id":"oai:doshisha.repo.nii.ac.jp:00027643","sets":["4151:8699:4187:4188","4251:7205:7206:8773:7207"]},"author_link":["28585"],"item_1693813220986":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1694497428290":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(工学)","subitem_degreename_language":"ja"}]},"item_1694497507610":{"attribute_name":"学位名（英）","attribute_value_mlt":[{"subitem_degreename":"Doctor of Philosophy in Engineering","subitem_degreename_language":"en"}]},"item_1694497573527":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"同志社大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Doshisha University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"34310","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_3_alternative_title_2":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"医薬品原薬の粒子物性に影響する界面の微視的挙動に関する研究","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"イヤクヒン ゲンヤク ノ リュウシ ブッセイ ニ エイキョウ スル カイメン ノ ビシテキ キョドウ ニカンスル ケンキュウ","subitem_alternative_title_language":"ja-Kana"}]},"item_3_date_granted_27":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2020-09-19"}]},"item_3_description_12":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"実験・理論・数値シミュレーションに加え，データ科学（統計解析）も含めたアプローチを活用し、低分子医薬品の原薬粒子形態に影響を与える界面現象に対してメカニズムを検討した。具体的には液－液相互拡散を伴う系での相互拡散現象、結晶核生成機構について分子動力学シミュレーション、また粉砕工程での共粉砕物間の固－固界面でのアモルファス化について離散要素法シミュレーションと統計的手法の組合せによる解析を行った。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"The mechanisms of interfacial phenomena affecting the particle morphology of small-molecule drugs were investigated using experimental, theoretical and numerical simulations as well as data science (statistical analysis). The mechanisms of mutual diffusion and crystal nucleation in systems with liquid-liquid interface were studied by molecular dynamics simulations, and amorphization at the solid-solid interface between co-milled materials during milling process was simulated by a combination of discrete element method and statistical methods.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_3_description_18":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_3_dissertation_number_28":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第1108号"}]},"item_3_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.14988/00027635","subitem_identifier_reg_type":"JaLC"}]},"item_3_relation_16":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"BC08225603","subitem_relation_type_select":"NCID"}}]},"item_3_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"掲載刊行物所蔵情報へのリンク ／ Link to 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