{"created":"2023-07-27T07:46:55.709563+00:00","id":21418,"links":{},"metadata":{"_buckets":{"deposit":"7e46bca8-4063-43e5-bfbe-ddd799386720"},"_deposit":{"created_by":20,"id":"21418","owners":[20],"pid":{"revision_id":0,"type":"depid","value":"21418"},"status":"published"},"_oai":{"id":"oai:doshisha.repo.nii.ac.jp:00021418","sets":["4251:8393:8394:8395:8410","8:3372:3812:3827"]},"author_link":["17791","16525","3383","16523","17792","17793","17794","16526"],"item_1693811493084":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1694490770713":{"attribute_name":"権利者情報","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"DA03974933","nameIdentifierScheme":"AID"}],"rightHolderNames":[{"rightHolderLanguage":"ja","rightHolderName":"同志社大学理工学研究所"},{"rightHolderLanguage":"en","rightHolderName":"Science and Engineering Research Institute of Doshisha University"}]}]},"item_1_alternative_title_2":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"新規癒着防止材熱架橋ゼラチンフィルムの物理的生物学的特性 : 癒着防止効果の機序及び腸管吻合部への影響に対する基礎的検討","subitem_alternative_title_language":"ja"}]},"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-07-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"155","bibliographicPageStart":"149","bibliographicVolumeNumber":"52","bibliographic_titles":[{"bibliographic_title":"同志社大学理工学研究報告","bibliographic_titleLang":"ja"},{"bibliographic_title":"The Science and Engineering Review of Doshisha University","bibliographic_titleLang":"en"}]}]},"item_1_description_12":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"我々は腹部外科手術後の癒着障害の予防軽減を行う為、新規癒着防止膜である熱架橋ゼラチンフィルムを開発作成し、これまで犬を用いた実験にてその優れた癒着防止効果と消化管吻合部に対しても安全に使用できることを報告してきた。今回我々は、熱架橋ゼラチンフィルムの物理的・生物学的特性について基礎的解析を行い、現在臨床で汎用されている癒着防止膜であるセプラフィルム(ヒアルロン酸とメチルセルロースの合材)とそれぞれ比較することにより、その操作性や癒着防止や吻合部への影響等の機序について予備的検討を行ったので報告する。最初に本材とセルロースフィルム(セプラフィルム○R)の引張揃断応力を測定した結果、特にフィルムを90°ひねった状態で牽引した場合、乾燥状態においても湿潤状態おいても、本材はセルロースフィルムに対し有意に強度を保つ事が分かった。次に各フィルムの溶解性試験を行ったところ、本材とセルロースフィルムは類似した溶解性を持ち、約7日間かけて徐々に70-80%溶解していた。一方、各フィルム上での細胞増殖と生死判定試験を行ったところ、ゼラチンフィルム上では経時的な細胞の増殖を認めたのに対し、セルロースフィルム上においては顕著に細胞数の減少がみられ、さらに5日目にはほぼすべての細胞が死滅することが確認された。以上のことから、熱架橋ゼラチンフィルムはセルロースフィルムに比べ、物理的強度が認められ、より操作性に優れると考えられた。セルロースフィルム及びゼラチンフィルムはどちらも腹膜損傷部において癒着形成に重要な約7日間程度物理的なバリアとして存在することで癒着防止をすると考えられるが、セルロースフィルムは細胞増殖を阻害する事で創治癒にも抑制的に作用するのに対し、熱架橋ゼラチンフィルムはそれらを抑制せず、結果的により良好な創傷治癒を伴う癒着防止効果があり、また腸管吻合部においても安全に使用できると考えられた。結論として熱架橋ゼラチンフィルムは吻合部に使用しても負の影響のない優れた癒着防止材であることを報告する。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"To prevent postoperative abdominal adhesion, we have developed a novel anti-adhesive material made of thermally cross-linked gelatin film. Previously, we reported that it had an excellent anti-adhesive effect and that it could be used safely for intestinal anastomosis in a canine model. This study analyzed the physical and biological properties of the thermally cross-linked gelatin film preliminarily, and investigated the handling and the mechanism of anti-adhesive effect and the influence on intestinal anastomotic sites, in comparison to a combination film composed of hyaluronic acid and carboxymethyl cellulose (cellulose film), that is commonly used in clinical situations. The tensile strength of the thermally cross-linked gelatin film was significantly higher than that of cellulose film when twisted to 90° in both wet and dry conditions. A degradation test in distilled water showed both films dissolved gradually with time and were nearly 70-80% dissolved by seven days. This suggested that these films have similar solubility. Tests of in vitro cell growth and viability on each film showed that cultured cells grew well over time on the thermally cross-linked gelatin film. On the other hand, the cell number decreased significantly on cellulose film and most of the cells died within seven days. These results suggest the thermally cross-linked gelatin film had more physical strength and better handling than cellulose film. Both thermally cross-linked gelatin film and cellulose film were thought to prevent adhesion as physical barrier during seven days after surgery, which is a significant period for adhesion formation. However the results also suggested that the cellulose film acted as anti-adhesive membrane by inhibiting cell growth and wound healing. In contrast, the thermally cross-linked gelatin film did not inhibit cell growth, and resulted in more favorable wound healing as well as anti-adhesive effects. Therefore, it could be used safely for intestinal anastomosis. In conclusion, the thermally cross-linked gelatin film is considered to be an excellent anti-adhesive material that has no negative effects on intestinal anastomosis sites.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_1_description_25":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_1_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.14988/pa.2017.0000012471","subitem_identifier_reg_type":"JaLC"}]},"item_1_publisher_15":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"同志社大学理工学研究所","subitem_publisher_language":"ja"}]},"item_1_publisher_16":{"attribute_name":"出版者（英）","attribute_value_mlt":[{"subitem_publisher":"Science and Engineering Research Institute of Doshisha University","subitem_publisher_language":"en"}]},"item_1_relation_24":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"掲載刊行物所蔵情報へのリンク ／ Link to Contents"}],"subitem_relation_type":"isFormatOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doors.doshisha.ac.jp/opac/opac_link/bibid/SB00960326/?lang=0","subitem_relation_type_select":"URI"}}]},"item_1_source_id_17":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00368172","subitem_source_identifier_type":"PISSN"}]},"item_1_source_id_19":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00165868","subitem_source_identifier_type":"NCID"}]},"item_1_subject_27":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"464.26","subitem_subject_scheme":"NDC"}]},"item_1_text_8":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"丹澤, あゆみ / Undergraduate Senior, Department of Medical Life Systems, Doshisha University"},{"subitem_text_language":"ja","subitem_text_value":"辻本, 洋行 / 同志社大学生命医科学部医生命システム学科"},{"subitem_text_language":"ja","subitem_text_value":"的場, 麻理 / Undergraduate Senior, Department of Medical Life Systems, Doshisha University"},{"subitem_text_language":"ja","subitem_text_value":"橋本, 歩 / 同志社大学生命医科学部医生命システム学科"},{"subitem_text_language":"ja","subitem_text_value":"鈴木, 周子 / Faculty of Medicine, Nara Medical University"},{"subitem_text_language":"ja","subitem_text_value":"森田, 真一郎 / Bio-Medical Material Research Center, Doshisha University"},{"subitem_text_language":"ja","subitem_text_value":"筏, 義人 / Faculty of Medicine, Nara Medical University"},{"subitem_text_language":"ja","subitem_text_value":"萩原, 明郎 / 同志社大学生命医科学部医生命システム学科教授"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"丹澤, あゆみ","creatorNameLang":"ja"},{"creatorName":"タンザワ, アユミ","creatorNameLang":"ja-Kana"},{"creatorName":"Tanzawa, Ayumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"17791","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000018513429","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000018513429"}]},{"creatorNames":[{"creatorName":"辻本, 洋行","creatorNameLang":"ja"},{"creatorName":"ツジモト, ヒロユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Tsujimoto, Hiroyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16525","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000020521272","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000020521272"},{"nameIdentifier":"20521272","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20521272"}]},{"creatorNames":[{"creatorName":"的場, 麻理","creatorNameLang":"ja"},{"creatorName":"マトバ, マリ","creatorNameLang":"ja-Kana"},{"creatorName":"Matoba, Mari","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3383","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000018513430","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000018513430"}]},{"creatorNames":[{"creatorName":"橋本, 歩","creatorNameLang":"ja"},{"creatorName":"ハシモト, アユミ","creatorNameLang":"ja-Kana"},{"creatorName":"Hashimoto, Ayumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16523","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1410290699890457089","nameIdentifierScheme":"CiNii Research","nameIdentifierURI":"https://cir.nii.ac.jp/crid/1410290699890457089"}]},{"creatorNames":[{"creatorName":"鈴木, 周子","creatorNameLang":"ja"},{"creatorName":"スズキ, シュウコ","creatorNameLang":"ja-Kana"},{"creatorName":"Suzuki, Syuko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"17792","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000018513431","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000018513431"}]},{"creatorNames":[{"creatorName":"森田, 真一郎","creatorNameLang":"ja"},{"creatorName":"モリタ, シンイチロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Morita, Shinichiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"17793","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000005708483","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000005708483"}]},{"creatorNames":[{"creatorName":"筏, 義人","creatorNameLang":"ja"},{"creatorName":"イカダ , ヨシト","creatorNameLang":"ja-Kana"},{"creatorName":"Ikada, Yoshito","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"17794","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000000025909","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000000025909"},{"nameIdentifier":"00025909","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=00025909"}]},{"creatorNames":[{"creatorName":"萩原, 明郎","creatorNameLang":"ja"},{"creatorName":"ハギワラ, アケオ","creatorNameLang":"ja-Kana"},{"creatorName":"Hagiwara, Akeo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16526","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000090198648","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000090198648"},{"nameIdentifier":"90198648","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90198648"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2011-08-22"}],"displaytype":"detail","filename":"023052020008.pdf","filesize":[{"value":"4.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"023052020008.pdf","url":"https://doshisha.repo.nii.ac.jp/record/21418/files/023052020008.pdf"},"version_id":"a09f5802-fb46-4539-a673-9259f38a4cc4"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"癒着防止","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"ゼラチン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"熱架橋","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"anti-adhesion","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"gelatin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"thermally cross-link","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"新規癒着防止材熱架橋ゼラチンフィルムの物理的・生物学的特性 : 癒着防止効果の機序及び腸管吻合部への影響に対する基礎的検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"新規癒着防止材熱架橋ゼラチンフィルムの物理的・生物学的特性 : 癒着防止効果の機序及び腸管吻合部への影響に対する基礎的検討","subitem_title_language":"ja"},{"subitem_title":"シンキ ユチャク ボウシザイ ネツカキョウ ゼラチン フィルム ノ ブツリテキ セイブツガクテキ トクセイ : ユチャク ボウシ コウカ ノ キジョ オヨビ チョウカン フンゴウブ エノ エイキョウ ニタイスル キソテキ ケントウ","subitem_title_language":"ja-Kana"},{"subitem_title":"Physical and biological properties of a novel anti-adhesive material made of thermally cross-linked gelatin film : preliminary study for the mechanism of the anti-adhesive effect and influence on intestinal anastomosis","subitem_title_language":"en"}]},"item_type_id":"1","owner":"20","path":["3827","8410"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2011-08-22"},"publish_date":"2011-08-22","publish_status":"0","recid":"21418","relation_version_is_last":true,"title":["新規癒着防止材熱架橋ゼラチンフィルムの物理的・生物学的特性 : 癒着防止効果の機序及び腸管吻合部への影響に対する基礎的検討"],"weko_creator_id":"20","weko_shared_id":-1},"updated":"2023-12-06T00:29:04.966897+00:00"}