{"created":"2024-04-24T07:12:50.406192+00:00","id":2000443,"links":{},"metadata":{"_buckets":{"deposit":"07d6fcec-1a67-4991-acbd-ce9df5a0d61f"},"_deposit":{"created_by":20,"id":"2000443","owners":[20],"pid":{"revision_id":0,"type":"depid","value":"2000443"},"status":"published"},"_oai":{"id":"oai:doshisha.repo.nii.ac.jp:02000443","sets":["4151:8699:4187:4188","4251:7205:7206:8773:7207"]},"author_link":["31292"],"item_1693813220986":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1694497428290":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(工学)","subitem_degreename_language":"ja"}]},"item_1694497507610":{"attribute_name":"学位名（英）","attribute_value_mlt":[{"subitem_degreename":"Doctor of Philosophy in Engineering","subitem_degreename_language":"en"}]},"item_1694497573527":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"同志社大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Doshisha University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"34310","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_3_date_granted_27":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2024-03-22"}]},"item_3_description_12":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"現在臨床利用されている抗がん剤は，正常細胞とがん細胞の両者に作用するため，強い副作用を示す．私は，がん細胞選択的な抗がん剤の開発に向け，正常細胞とは異なるがん細胞の微小環境(正常細胞に比べて，活性酸素種濃度や還元剤濃度が高いこと)に着目した．本論文では，活性酸素種の一種である過酸化水素との反応ないしは還元剤による酸素活性化で細胞毒性を示す様々なamide-tether型二核銅錯体を開発した．これらの錯体の構造機能相関を調べることで，がん細胞選択的な細胞毒性に効果的な構造特性の知見を得た．","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Anticancer drugs currently in clinical use have strong side effects because they act on both normal cells and cancer cells. To develop cancer cell-selective anticancer drugs, I focused on the specific environment of cancer cells, which is different from that of normal cells (higher concentrations of reactive oxygen species and reducing agents than normal cells). In this paper, I developed various amide-tether dicopper complexes that exhibit cytotoxicity through reaction with hydrogen peroxide, a type of reactive oxygen species, or upon oxygen activation by reducing agents. By investigating the structure-function relationships of these complexes, I obtained knowledge of structural characteristics that are effective for cancer cell-selective cytotoxicity.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_3_description_18":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_3_dissertation_number_28":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第1345号"}]},"item_3_text_8":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"理工学研究科"}]},"item_3_text_9":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Graduate School of Science and Engineering"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"畑, 真知","creatorNameLang":"ja"},{"creatorName":"ハタ, マチ","creatorNameLang":"ja-Kana"},{"creatorName":"Hata, Machi","creatorNameLang":"en"}],"familyNames":[{"familyName":"畑","familyNameLang":"ja"},{"familyName":"ハタ","familyNameLang":"ja-Kana"},{"familyName":"Hata","familyNameLang":"en"}],"givenNames":[{"givenName":"真知","givenNameLang":"ja"},{"givenName":"マチ","givenNameLang":"ja-Kana"},{"givenName":"Machi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"31292","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1380861286472401154","nameIdentifierScheme":"CiNii Research","nameIdentifierURI":"https://cir.nii.ac.jp/crid/1380861286472401154"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2024-05-07"}],"displaytype":"detail","filename":"k1345.pdf","filesize":[{"value":"312KB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"要旨/abstaract","objectType":"abstract","url":"https://doshisha.repo.nii.ac.jp/record/2000443/files/k1345.pdf"},"version_id":"2d0d71b6-aabd-422e-9741-57e795277690"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2024-12-18"}],"displaytype":"detail","filename":"zk1345.pdf","filesize":[{"value":"20.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"zk1345.pdf","objectType":"fulltext","url":"https://doshisha.repo.nii.ac.jp/record/2000443/files/zk1345.pdf"},"version_id":"c40e48ba-312c-414c-8452-d2e4fa39f6db"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"抗がん剤","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"二核銅錯体","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"がん細胞選択的毒性","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"DNA切断活性","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"DNA標的能","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Anti-cancer agent","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Dicopper complex","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cancer-selective cytotoxicity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"DNA cleavage activity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"DNA targeting ability","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"がん細胞選択的毒性を発現する二核銅錯体の開発及びその構造機能相関の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"がん細胞選択的毒性を発現する二核銅錯体の開発及びその構造機能相関の解明","subitem_title_language":"ja"},{"subitem_title":"ガン サイボウ センタクテキ ドクセイ オ ハツゲン スル ニカク ドウ サクタイ ノ カイハツ オヨビ ソノ コウゾウ キノウ ソウカン ノ カイメイ","subitem_title_language":"ja-Kana"}]},"item_type_id":"3","owner":"20","path":["4188","7207"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-05-07"},"publish_date":"2024-05-07","publish_status":"0","recid":"2000443","relation_version_is_last":true,"title":["がん細胞選択的毒性を発現する二核銅錯体の開発及びその構造機能相関の解明"],"weko_creator_id":"20","weko_shared_id":-1},"updated":"2024-12-20T06:07:12.513392+00:00"}