{"created":"2023-10-16T01:01:54.346449+00:00","id":2000101,"links":{},"metadata":{"_buckets":{"deposit":"a6c22a95-3dcd-439c-8c2b-f712a16a7a87"},"_deposit":{"created_by":20,"id":"2000101","owner":"20","owners":[20],"pid":{"revision_id":0,"type":"depid","value":"2000101"},"status":"published"},"_oai":{"id":"oai:doshisha.repo.nii.ac.jp:02000101","sets":["4151:8699:4190:4192","4251:7209:7210:8775:7212"]},"author_link":["31071","17121"],"control_number":"2000101","item_1693813220986":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1694497428290":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(理学)","subitem_degreename_language":"ja"}]},"item_1694497507610":{"attribute_name":"学位名（英）","attribute_value_mlt":[{"subitem_degreename":"Doctor of Philosophy in Science","subitem_degreename_language":"en"}]},"item_1694497573527":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"同志社大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Doshisha University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"34310","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_3_alternative_title_2":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"RAW264.7細胞のin vitro破骨細胞形成モデルにおける細胞内および細胞外AGEsの役割","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"RAW 264.7 サイボウ ノ in vitro ハコツ サイボウ ケイセイ モデル ニオケル サイボウナイ オヨビ サイボウガイ AGEs ノ ヤクワリ","subitem_alternative_title_language":"ja-Kana"}]},"item_3_contributor_35":{"attribute_name":"指導教員","attribute_value_mlt":[{"contributorNames":[{"contributorName":"米井, 嘉一","lang":"ja"},{"contributorName":"ヨネイ, ヨシカズ","lang":"ja-Kana"},{"contributorName":"Yonei, Yoshikazu","lang":"en"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{"nameIdentifier":"17121","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000040191655","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000040191655"},{"nameIdentifier":"40191655","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40191655"},{"nameIdentifier":"0000-0002-2682-752X","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0002-2682-752X"},{"nameIdentifier":"DA13348772","nameIdentifierScheme":"AID","nameIdentifierURI":"https://ci.nii.ac.jp/author/DA13348772"}]}]},"item_3_date_granted_27":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2023-09-20"}]},"item_3_description_12":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"糖化ストレスとAGEsは骨粗鬆症の発症・進展に関与する。細胞内AGEs形成は、細胞間融合を減少させ、破骨細胞分化遺伝子の発現を抑制することにより破骨細胞形成を低下させた。一方、細胞外AGEsは、糖化剤によって異なるシグナル伝達経路を活性化することにより、破骨細胞新生を刺激する作用を示した。遊離ペントシジンは破骨細胞新生を有意に抑制したが、これは破骨細胞新生に対するフィードバック阻害である可能性が考えられた。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Glycative stress and AGEs are reported to be associated with metabolic diseases. Osteoporosis is characterized by excess bone resorption by osteoclasts followed by reduced bone formation by osteoblasts. Pentosidine has been reported to be elevated in osteoporotic patients' serum, forming an abnormal cross-link with collagen protein, and reducing bone quality.\nIntracellular AGE formation reduces osteoclastogenesis by reducing cell-cell fusion and inhibiting osteoclastogenic gene expression. In contrast, extracellular AGEs showed stimulatory effects on osteoclastogenesis by activating different signaling pathways depending on the glycating agent; whereas free pentosidine significantly reduced osteoclastogenesis which could be feedback inhibition on osteoclastogenesis.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_3_description_18":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_3_dissertation_number_28":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第1314号"}]},"item_3_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.14988/0002000101","subitem_identifier_reg_type":"JaLC"}]},"item_3_text_8":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"生命医科学研究科"}]},"item_3_text_9":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Graduate School of Life and Medical Sciences"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Lucy, Tarannum Tanzima","creatorNameLang":"en"}],"familyNames":[{"familyName":"Lucy","familyNameLang":"en"}],"givenNames":[{"givenName":"Tarannum Tanzima","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"31071","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"0000-0002-5794-5174","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0002-5794-5174"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-10-18"}],"displaytype":"detail","filename":"k1314.pdf","filesize":[{"value":"305.6KB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"要旨/abstaract","objectType":"abstract","url":"https://doshisha.repo.nii.ac.jp/record/2000101/files/k1314.pdf"},"version_id":"7329e83b-ef01-42b5-a3b1-805982d0ee5c"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-07-24"}],"displaytype":"detail","filename":"zk1314.pdf","filesize":[{"value":"10 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://doshisha.repo.nii.ac.jp/record/2000101/files/zk1314.pdf"},"version_id":"fb7a8382-555f-4a77-9872-6b2a93e45326"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"破骨細胞形成","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞内AGE","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"コラーゲン-I","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"ペントシジン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"osteoclastogenesis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"RANKL","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"intracellular AGE","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"collagen-I","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"pentosidine","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"},{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"The role of intracellular and extracellular AGEs on in vitro osteoclastogenic model of RAW 264.7 cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The role of intracellular and extracellular AGEs on in vitro osteoclastogenic model of RAW 264.7 cells","subitem_title_language":"en"}]},"item_type_id":"3","owner":"20","path":["4192","7212"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-10-18"},"publish_date":"2023-10-18","publish_status":"0","recid":"2000101","relation_version_is_last":true,"title":["The role of intracellular and extracellular AGEs on in vitro osteoclastogenic model of RAW 264.7 cells"],"weko_creator_id":"20","weko_shared_id":-1},"updated":"2024-07-25T00:31:01.663981+00:00"}