{"created":"2023-07-27T07:30:50.366682+00:00","id":1622,"links":{},"metadata":{"_buckets":{"deposit":"a3b151cf-2e44-44f4-b759-c2fddf901222"},"_deposit":{"created_by":20,"id":"1622","owners":[20],"pid":{"revision_id":0,"type":"depid","value":"1622"},"status":"published"},"_oai":{"id":"oai:doshisha.repo.nii.ac.jp:00001622","sets":["4151:8699:4203:4204","4251:7687:7688:8785:7689"]},"author_link":["3505"],"item_1693813220986":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1694497428290":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(理学)","subitem_degreename_language":"ja"}]},"item_1694497507610":{"attribute_name":"学位名（英）","attribute_value_mlt":[{"subitem_degreename":"Doctor of Philosophy in Science","subitem_degreename_language":"en"}]},"item_1694497573527":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"同志社大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Doshisha University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"34310","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_3_alternative_title_2":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"神経細胞におけるタウ蛋白質軸索局在化メカニズムの研究","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"シンケイ サイボウ ニオケル タウ タンパクシツ ジクサク キョクザイカ メカニズム ノ ケンキュウ","subitem_alternative_title_language":"ja-Kana"}]},"item_3_date_granted_27":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2020-03-22"}]},"item_3_description_12":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"微小管結合タンパク質の1つであるタウは、神経細胞の軸索に特異的に局在している。タウの軸索局在化分子機序を解明するために、外因性タウを神経細胞の発達初期に一時的に発現させ、軸索特異的に局在させる方法を構築した。この方法を用い、proline rich region 2 (PRR2)がタウの軸索局在化に重要であること、PRR2のリン酸化が軸索への移動に関与することを示唆した。またこの系の確立は局在や細胞内動態などの検討を行うことを可能にした。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Microtubule-associated protein tau localizes specifically to neuronal axons. In order to elucidate the molecular mechanism of the axon localization of tau, we constructed an expression system for axon specific localization of exogenous tau in immature neurons in culture. Using this system, it suggested that the proline rich region 2 (PRR2) and phosphorylation of PRR2, which contains important phosphorylation sites, is critical for the localization.  In the future, this experimental system will contribute greatly to the study of tau in normal and in the pathology of Alzheimer's disease.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_3_description_18":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_3_dissertation_number_28":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第1093号"}]},"item_3_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.14988/00001614","subitem_identifier_reg_type":"JaLC"}]},"item_3_relation_16":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"BC05527468","subitem_relation_type_select":"NCID"}}]},"item_3_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"掲載刊行物所蔵情報へのリンク ／ Link to Contents"}],"subitem_relation_type":"isFormatOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doors.doshisha.ac.jp/opac/opac_link/bibid/BB13142995/?lang=0","subitem_relation_type_select":"URI"}}]},"item_3_text_8":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"脳科学研究科"}]},"item_3_text_9":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Graduate School of Brain Science"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"岩田, 実里","creatorNameLang":"ja"},{"creatorName":"イワタ, ミノリ","creatorNameLang":"ja-Kana"},{"creatorName":"Iwata, Minori","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-05-28"}],"displaytype":"detail","filename":"k1093.pdf","filesize":[{"value":"306.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"要旨/abstaract","objectType":"abstract","url":"https://doshisha.repo.nii.ac.jp/record/1622/files/k1093.pdf"},"version_id":"a780beb8-81a4-45ff-9bd2-f56f2906613f"},{"accessrole":"open_access","displaytype":"detail","filename":"zk1093.pdf","filesize":[{"value":"3.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://doshisha.repo.nii.ac.jp/record/1622/files/zk1093.pdf"},"version_id":"02e2bf1c-6b10-41ea-8683-c7dbdf8f631c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"tau protein","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"axonal localization","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"proline rich region 2","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Study of mechanisms for the axonal localization of the tau protein in neurons","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Study of mechanisms for the axonal localization of the tau protein in neurons","subitem_title_language":"en"}]},"item_type_id":"3","owner":"20","path":["4204","7689"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-06-01"},"publish_date":"2020-06-01","publish_status":"0","recid":"1622","relation_version_is_last":true,"title":["Study of mechanisms for the axonal localization of the tau protein in neurons"],"weko_creator_id":"20","weko_shared_id":-1},"updated":"2023-12-20T00:30:00.872768+00:00"}