{"created":"2023-07-27T07:30:46.864780+00:00","id":1550,"links":{},"metadata":{"_buckets":{"deposit":"0bf7816b-8ee2-4150-81b5-6b0fda6ae18a"},"_deposit":{"created_by":20,"id":"1550","owners":[20],"pid":{"revision_id":0,"type":"depid","value":"1550"},"status":"published"},"_oai":{"id":"oai:doshisha.repo.nii.ac.jp:00001550","sets":["4151:8699:4203:4204","4251:7687:7688:8785:7689"]},"author_link":["3393"],"item_1693813220986":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1694497428290":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(理学)","subitem_degreename_language":"ja"}]},"item_1694497507610":{"attribute_name":"学位名（英）","attribute_value_mlt":[{"subitem_degreename":"Doctor of Philosophy in Science","subitem_degreename_language":"en"}]},"item_1694497573527":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"同志社大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Doshisha University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"34310","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_3_alternative_title_2":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"ハンチントン病モデルマウスの中型有棘神経細胞におけるノンコーディングRNAの発現変化","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"ハンチントンビョウ モデル マウス ノ チュウガタ ユウキョク シンケイ サイボウ ニオケル ノンコーディング RNA ノ ハツゲン ヘンカ","subitem_alternative_title_language":"ja-Kana"}]},"item_3_date_granted_27":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2019-03-22"}]},"item_3_description_12":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Huntington Disease (HD) is a neurodegenerative disorder caused by expanded CAG repeats in the exon1 of huntingtin gene (HTT). The mutant HTT affects the transcriptional profile of neurons by disrupting the activities of transcriptional machinery and alters expression of many genes. In this study, we identified dysregulated non-coding RNAs (ncRNAs) in medium spiny neurons of 4-week-old HD model mouse. Also, we observed the intracellular localizations of Abhd11os and Neat1 ncRNAs by ViewRNA in situ hybridization, which could provide more precise detection, suggesting that it is a useful method to investigate the expression changes of genes with low expression levels.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_3_description_18":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_3_dissertation_number_28":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第1031号"}]},"item_3_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.14988/di.2019.0000000594","subitem_identifier_reg_type":"JaLC"}]},"item_3_relation_16":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"BB29390837","subitem_relation_type_select":"NCID"}}]},"item_3_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"掲載刊行物所蔵情報へのリンク ／ Link to Contents"}],"subitem_relation_type":"isFormatOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doors.doshisha.ac.jp/opac/opac_link/bibid/BB13106336/?lang=0","subitem_relation_type_select":"URI"}}]},"item_3_text_8":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"脳科学研究科"}]},"item_3_text_9":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Graduate School of Brain Science"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"朴, 洪宣","creatorNameLang":"ja"},{"creatorName":"パク, ホンソン","creatorNameLang":"ja-Kana"},{"creatorName":"Park, Hongsun","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-05-17"}],"displaytype":"detail","filename":"k1031.pdf","filesize":[{"value":"369.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"要旨/abstaract","objectType":"abstract","url":"https://doshisha.repo.nii.ac.jp/record/1550/files/k1031.pdf"},"version_id":"7515ecc3-190b-436b-9387-b42c8319ce07"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-05"}],"displaytype":"detail","filename":"zk1031.pdf","filesize":[{"value":"12.9 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"zk1031.pdf","objectType":"fulltext","url":"https://doshisha.repo.nii.ac.jp/record/1550/files/zk1031.pdf"},"version_id":"33f609ed-a00f-4655-9292-217b7f869158"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Gene expression","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Non-coding RNA","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Huntington disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Abhd11os","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Neat1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ViewRNA in situ hybridization","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Microarray","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Analysis of non-coding RNA expression in medium spiny neurons of Huntington disease model mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Analysis of non-coding RNA expression in medium spiny neurons of Huntington disease model mice","subitem_title_language":"en"}]},"item_type_id":"3","owner":"20","path":["4204","7689"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-05-20"},"publish_date":"2019-05-20","publish_status":"0","recid":"1550","relation_version_is_last":true,"title":["Analysis of non-coding RNA expression in medium spiny neurons of Huntington disease model mice"],"weko_creator_id":"20","weko_shared_id":-1},"updated":"2023-12-20T00:29:51.044234+00:00"}