{"created":"2023-07-27T07:30:43.847409+00:00","id":1487,"links":{},"metadata":{"_buckets":{"deposit":"cc8c434c-334d-42f3-a0f9-83fe02649ad8"},"_deposit":{"created_by":20,"id":"1487","owners":[20],"pid":{"revision_id":0,"type":"depid","value":"1487"},"status":"published"},"_oai":{"id":"oai:doshisha.repo.nii.ac.jp:00001487","sets":["4151:8699:4190:4192","4251:7209:7210:8775:7212"]},"author_link":["3258"],"item_1693813220986":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1694497428290":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(理学)","subitem_degreename_language":"ja"}]},"item_1694497507610":{"attribute_name":"学位名（英）","attribute_value_mlt":[{"subitem_degreename":"Doctor of Philosophy in Science","subitem_degreename_language":"en"}]},"item_1694497573527":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"同志社大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Doshisha University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"34310","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_3_alternative_title_2":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"アルツハイマー病原因物質アミロイドβ産生制御に関する研究 : Nicastrin糖鎖修飾とTetraspanin-7によるγセクレターゼ活性変化","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"アルツハイマービョウ ゲンイン ブッシツ アミロイドβ サンセイ セイギョ ニカンスル ケンキュウ : Nicastrin トウサ シュウショク ト Tetraspanin-7 ニヨル γセクレターゼ カッセイ ヘンカ","subitem_alternative_title_language":"ja-Kana"}]},"item_3_date_granted_27":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2018-09-20"}]},"item_3_description_12":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"This study examined the effect of nicastrin glycosylation on γ-secretase activity and substrate specificity in a group of glycosylation mutant CHO (Lec) cells. I have also searched for non-raft tetraspanins by proteomics analysis; and then examined the effect of identified tetraspanins on amyloid-β production. Findings of this thesis suggest that thorough glycosylation of nicastrin is critical for enzymatic activity and substrate preference of γ-secretase; and tetraspanin-7 is a potent modulator of amyloid-β production.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_3_description_18":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_3_dissertation_number_28":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第970号"}]},"item_3_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.14988/di.2019.0000000180","subitem_identifier_reg_type":"JaLC"}]},"item_3_relation_16":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"BB27826046","subitem_relation_type_select":"NCID"}}]},"item_3_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"掲載刊行物所蔵情報へのリンク ／ Link to Contents"}],"subitem_relation_type":"isFormatOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doors.doshisha.ac.jp/opac/opac_link/bibid/BB13080171/?lang=0","subitem_relation_type_select":"URI"}}]},"item_3_text_8":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"生命医科学研究科"}]},"item_3_text_9":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Graduate School of Life and Medical Sciences"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Moniruzzaman, Mohammad","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-10-10"}],"displaytype":"detail","filename":"k970.pdf","filesize":[{"value":"247.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"要旨/abstaract","objectType":"abstract","url":"https://doshisha.repo.nii.ac.jp/record/1487/files/k970.pdf"},"version_id":"ce4ce392-9c0a-4aa7-a9a4-7dae0f5d58f7"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-07-31"}],"displaytype":"detail","filename":"zk970.pdf","filesize":[{"value":"18.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"zk970.pdf","objectType":"fulltext","url":"https://doshisha.repo.nii.ac.jp/record/1487/files/zk970.pdf"},"version_id":"a9f0d7c5-b84a-4d6d-97a0-899b6dba538b"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Regulation of amyloid-β production : studies of γ-secretase activity on nicastrin glycosylation and tetraspanin-7","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Regulation of amyloid-β production : studies of γ-secretase activity on nicastrin glycosylation and tetraspanin-7","subitem_title_language":"en"}]},"item_type_id":"3","owner":"20","path":["4192","7212"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-10-12"},"publish_date":"2018-10-12","publish_status":"0","recid":"1487","relation_version_is_last":true,"title":["Regulation of amyloid-β production : studies of γ-secretase activity on nicastrin glycosylation and tetraspanin-7"],"weko_creator_id":"20","weko_shared_id":-1},"updated":"2023-12-20T07:02:18.122252+00:00"}