{"created":"2023-07-27T07:30:39.252639+00:00","id":1391,"links":{},"metadata":{"_buckets":{"deposit":"ae0a9b3e-890a-4c07-81bc-14c6ca0ecb37"},"_deposit":{"created_by":20,"id":"1391","owners":[20],"pid":{"revision_id":0,"type":"depid","value":"1391"},"status":"published"},"_oai":{"id":"oai:doshisha.repo.nii.ac.jp:00001391","sets":["4151:8699:4190:4192","4251:7209:7210:8775:7212"]},"author_link":["3065"],"item_1693813220986":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1694497428290":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(理学)","subitem_degreename_language":"ja"}]},"item_1694497507610":{"attribute_name":"学位名（英）","attribute_value_mlt":[{"subitem_degreename":"Doctor of Philosophy in Science","subitem_degreename_language":"en"}]},"item_1694497573527":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"同志社大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Doshisha University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"34310","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_3_alternative_title_2":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"糖化蛋白による破骨細胞分化への影響","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"トウカ タンパク ニヨル ハコツ サイボウ ブンカ エノ エイキョウ","subitem_alternative_title_language":"ja-Kana"}]},"item_3_date_granted_27":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2017-09-20"}]},"item_3_description_12":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Glycolaldehyde (Glycol) and glyceraldehyde (Glycer) derived glycated human serum albumin (HSA) significantly reduced RANKL-induced osteoclastic TRAP activity, while glucose, fructose, glyoxal derived glycated HSA have no effect. Secreted high mobility group box protein1 (HMGB1) bind to receptor for AGE (RAGE) and play an important role for osteoclastogenesis. Next, we investigated that the effect of glycated HSA on HMGB1 secretion and RAGE expression. Both Glycol-AGE and Glycer-AGE inhibited RANKL-induced HMGB1 secretion but not altered RAGE expression levels. These result indicated that some kinds of AGEs altered osteoclastic TRAP activity through inhibition of HMGB1 secretion from the cell.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_3_description_18":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_3_dissertation_number_28":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第880号"}]},"item_3_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.14988/di.2018.0000000147","subitem_identifier_reg_type":"JaLC"}]},"item_3_relation_16":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"BB26619523","subitem_relation_type_select":"NCID"}}]},"item_3_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"掲載刊行物所蔵情報へのリンク ／ Link to Contents"}],"subitem_relation_type":"isFormatOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doors.doshisha.ac.jp/opac/opac_link/bibid/BB13059543/?lang=0","subitem_relation_type_select":"URI"}}]},"item_3_text_8":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"生命医科学研究科"}]},"item_3_text_9":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Graduate School of Life and Medical Sciences"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mamun Or Rashid, A N M","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-18"}],"displaytype":"detail","filename":"k880.pdf","filesize":[{"value":"339.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"要旨/abstaract","objectType":"abstract","url":"https://doshisha.repo.nii.ac.jp/record/1391/files/k880.pdf"},"version_id":"9b2a5899-94ac-444d-979d-5b0d7d4d9d64"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-04"}],"displaytype":"detail","filename":"zk880.pdf","filesize":[{"value":"2.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"zk880.pdf","objectType":"fulltext","url":"https://doshisha.repo.nii.ac.jp/record/1391/files/zk880.pdf"},"version_id":"91e7f4a8-8b49-49cf-a504-cedbd65e59bb"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Modulation of in vitro osteoclastogenesis by glycated proteins","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Modulation of in vitro osteoclastogenesis by glycated proteins","subitem_title_language":"en"}]},"item_type_id":"3","owner":"20","path":["4192","7212"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-10-19"},"publish_date":"2017-10-19","publish_status":"0","recid":"1391","relation_version_is_last":true,"title":["Modulation of in vitro osteoclastogenesis by glycated proteins"],"weko_creator_id":"20","weko_shared_id":-1},"updated":"2023-12-20T07:02:13.461888+00:00"}