{"created":"2023-07-27T07:30:39.206228+00:00","id":1390,"links":{},"metadata":{"_buckets":{"deposit":"fd33e4d3-5ca9-4f50-8e55-15e96356bc8c"},"_deposit":{"created_by":20,"id":"1390","owners":[20],"pid":{"revision_id":0,"type":"depid","value":"1390"},"status":"published"},"_oai":{"id":"oai:doshisha.repo.nii.ac.jp:00001390","sets":["4151:8699:4190:4192","4251:7209:7210:8775:7212"]},"author_link":["3064"],"item_1693813220986":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1694497428290":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(理学)","subitem_degreename_language":"ja"}]},"item_1694497507610":{"attribute_name":"学位名（英）","attribute_value_mlt":[{"subitem_degreename":"Doctor of Philosophy in Science","subitem_degreename_language":"en"}]},"item_1694497573527":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"同志社大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Doshisha University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"34310","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_3_alternative_title_2":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"ガン細胞における転写因子NRF3(NFE2L3)の制御機構と機能","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"ガン サイボウ ニオケル テンシャ インシ NRF3(NFE2L3)ノ セイギョ キコウ ト キノウ","subitem_alternative_title_language":"ja-Kana"}]},"item_3_date_granted_27":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2017-09-20"}]},"item_3_description_12":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"I found multiple regulation of NRF3 activities promotes cell proliferation. My analyses reveal (1) under physiological conditions, NRF3 is rapidly degraded by the ER-associated degradation (ERAD) ubiquitin ligase HRD1 and valosin-containing protein (VCP) in the cytoplasm; (2) NRF3 is also degraded by β-TRCP, an adaptor for the Skp1-Cul1-F-box protein (SCF) ubiquitin ligase in the nucleus; (3) NRF3 mediates gene expression of the cell cycle regulator U2AF homology motif kinase 1 (UHMK1) for cell proliferation; (4) the nature of the activation mechanism of NRF3 is not the inhibition of its HRD1-VCP-mediated degradation. Collectively, this study provides us many insights into biological function of NRF3 in cancer cells.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_3_description_18":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_3_dissertation_number_28":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第879号"}]},"item_3_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.14988/di.2018.0000000146","subitem_identifier_reg_type":"JaLC"}]},"item_3_relation_16":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"BB26619090","subitem_relation_type_select":"NCID"}}]},"item_3_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"掲載刊行物所蔵情報へのリンク ／ Link to Contents"}],"subitem_relation_type":"isFormatOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doors.doshisha.ac.jp/opac/opac_link/bibid/BB13059542/?lang=0","subitem_relation_type_select":"URI"}}]},"item_3_text_8":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"生命医科学研究科"}]},"item_3_text_9":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Graduate School of Life and Medical Sciences"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Chowdhury, A M Masudul Azad","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3064","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"8000001731397","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/8000001731397"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-18"}],"displaytype":"detail","filename":"k879.pdf","filesize":[{"value":"179.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"要旨/abstaract","objectType":"abstract","url":"https://doshisha.repo.nii.ac.jp/record/1390/files/k879.pdf"},"version_id":"03d7caa8-88f6-4f84-b0d3-08b5d2ef2d09"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-06-29"}],"displaytype":"detail","filename":"zk879.pdf","filesize":[{"value":"2.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"zk879.pdf","objectType":"fulltext","url":"https://doshisha.repo.nii.ac.jp/record/1390/files/zk879.pdf"},"version_id":"51da4a7c-4b30-421b-a2d0-ad9ca10b0514"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Molecular regulation and biological function of NRF3 (NFE2L3) in cancer cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Molecular regulation and biological function of NRF3 (NFE2L3) in cancer cells","subitem_title_language":"en"}]},"item_type_id":"3","owner":"20","path":["4192","7212"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-10-19"},"publish_date":"2017-10-19","publish_status":"0","recid":"1390","relation_version_is_last":true,"title":["Molecular regulation and biological function of NRF3 (NFE2L3) in cancer cells"],"weko_creator_id":"20","weko_shared_id":-1},"updated":"2023-12-20T07:02:08.559162+00:00"}