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Regeneration and reinforcement of the aorta using scaffolds composed of biodegradable non-woven fabric in a dog experiment : a preliminary report for a rapid communication
https://doi.org/10.14988/pa.2017.0000014270
https://doi.org/10.14988/pa.2017.00000142709d910225-7f9b-401a-8842-9d5a7d82e46e
名前 / ファイル | ライセンス | アクション |
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023056030005.pdf (10.8 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||||||||
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公開日 | 2015-12-03 | |||||||||||
タイトル | ||||||||||||
言語 | en | |||||||||||
タイトル | Regeneration and reinforcement of the aorta using scaffolds composed of biodegradable non-woven fabric in a dog experiment : a preliminary report for a rapid communication | |||||||||||
言語 | ||||||||||||
言語 | eng | |||||||||||
キーワード | ||||||||||||
主題 | 大動脈再生, イヌによる実験, 生体内分解性ポリマー, 多層性再生足場 regeneration of aorta, dog experiment, biodegradable polymer, multi-layered scaffold |
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資源タイプ | ||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
資源タイプ | departmental bulletin paper | |||||||||||
ID登録 | ||||||||||||
ID登録 | 10.14988/pa.2017.0000014270 | |||||||||||
ID登録タイプ | JaLC | |||||||||||
アクセス権 | ||||||||||||
アクセス権 | open access | |||||||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
その他(別言語等)のタイトル | ||||||||||||
その他のタイトル | イヌにおける生体吸収性不織布からなる足場を用いた大動脈の再生と補強 : 速報のための予備的報告 | |||||||||||
言語 | ja | |||||||||||
その他(別言語等)のタイトル | ||||||||||||
その他のタイトル | イヌ ニオケル セイタイ キュウシュウセイ フショクフ カラ ナル アシバ オ モチイタ ダイドウミャク ノ サイセイ ト ホキョウ : ソクホウ ノ タメ ノ ヨビテキ ホウコク | |||||||||||
言語 | ja-Kana | |||||||||||
著者 |
萩原, 明郎
× 萩原, 明郎× 辻本, 洋行
WEKO
16525
× 高木, 敏貴× 宮本, 博恵× 山中, 皓暉× 莫, 秀梅× 筏, 義人× 奥村, 悟 |
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著者所属(英) | ||||||||||||
en | ||||||||||||
Hagiwara, Akeo / 同志社大学生命医科学部医生命システム学科教授 | ||||||||||||
著者所属(英) | ||||||||||||
en | ||||||||||||
Tsujimoto, Hiroyuki / Faculty of Life and Medical Sciences, Department of Medical Life Systems, Doshisha University | ||||||||||||
著者所属(英) | ||||||||||||
en | ||||||||||||
Takagi , Toshitaka / Faculty of Life and Medical Sciences, Department of Medical Life Systems, Doshisha University | ||||||||||||
著者所属(英) | ||||||||||||
en | ||||||||||||
Miyamoto, Hiroe / Graduate Student, Department of Medical Life System, Doshisha University | ||||||||||||
著者所属(英) | ||||||||||||
en | ||||||||||||
Yamanaka, Koki / Graduate Student, Department of Medical Life System, Doshisha University | ||||||||||||
著者所属(英) | ||||||||||||
en | ||||||||||||
Mo, Xiumei / Department of Biomaterials and Tissue Engineering, Donghua University | ||||||||||||
著者所属(英) | ||||||||||||
en | ||||||||||||
Ikada, Yoshito / Department of Bioenvironmental Medicine, Nara Medical University | ||||||||||||
著者所属(英) | ||||||||||||
en | ||||||||||||
Okumura, Satoru / Department of Cardiovascular Surgery, Kusatsu General Hospital | ||||||||||||
抄録 | ||||||||||||
内容記述タイプ | Abstract | |||||||||||
内容記述 | 大動脈を再生するため、多層の管状構造の新規の血管再生足場を開発した。最内層はエレクトロスピニング法で作成したラクチド/カプロラクトン・コポリマー布のチューブである。メルトブロウ法あるいは編んで作成したラクチド/カプロラクトン・コポリマー及びポリラクチド布のロールが最内層の上に巻いてある。吻合部の外層はメルトブロウ法で作成したポリグリコール酸布で覆われている。この多層性の血管用足場をイヌの大動脈に移植した。経時的な組織再生と移植片の分解の詳細をラットとイヌにおいて観察した。その結果、10月後には本来の大動脈と殆ど同じ構造の大動脈が再生された。最初はそれ自身はポリマーの布であった外側ポリマー布層は、移植後早期に、自己組織化した層に置き換わった。この外側層は、最内層の補強材の働きをしていると考えられた。最内層のチューブの布は本来の構造を保持しつつ徐々に分解された。結論として、この新規の血管再生足場は、イヌの大動脈の構造と殆ど同じ構造の大動脈を再生することが可能である。 | |||||||||||
言語 | ja | |||||||||||
抄録 | ||||||||||||
内容記述タイプ | Abstract | |||||||||||
内容記述 | To regenerate the aorta we devised a new vascular scaffold with multilayered tube structure. The innermost layer was a fabric tube made of poly (lactide/caprolactone) produced by electro-spinning method. Fabric roles of poly (lactide/caprolactone) and/or poly (lactide) produced by melt-blow or knit method were overlying the innermost layer. An outer layer of anastomotic site was covered with a role of poly (glycolic acid) fabric produced by melt-blow method. The multilayered vascular scaffold was implanted in the native abdominal aorta of dog. Chronological observation of tissue regeneration and graft degradation were also conducted in rats and dogs for detail analyses. The aorta was regenerated in 10 months in almost similar structure to the native aorta. In the early phase after implantation, the outer polymer layers, initially polymer fabrics themselves, were replaced by self-organizing membranes. The outer layers were considered to work for reinforcement of the innermost layer. The fabrics of innermost tube maintained the original structure and degraded slowly. In conclusion the new vascular scaffold can regenerate the canine aorta with almost similar structure to the native aorta. | |||||||||||
言語 | en | |||||||||||
書誌情報 |
ja : 同志社大学ハリス理化学研究報告 en : The Harris science review of Doshisha University 巻 56, 号 3, p. 166-172, 発行日 2015-10-31 |
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出版者 | ||||||||||||
言語 | ja | |||||||||||
出版者 | 同志社大学ハリス理化学研究所 | |||||||||||
出版者(英) | ||||||||||||
言語 | en | |||||||||||
出版者 | Harris Science Research Institute of Doshisha University | |||||||||||
ISSN | ||||||||||||
収録物識別子タイプ | PISSN | |||||||||||
収録物識別子 | 21895937 | |||||||||||
書誌レコードID | ||||||||||||
収録物識別子タイプ | NCID | |||||||||||
収録物識別子 | AA12716107 | |||||||||||
権利者情報 | ||||||||||||
権利者名 | 同志社大学ハリス理化学研究所 | |||||||||||
言語 | ja | |||||||||||
権利者名 | Harris Science Research Institute of Doshisha University | |||||||||||
言語 | en | |||||||||||
関連サイト | ||||||||||||
関連タイプ | isFormatOf | |||||||||||
識別子タイプ | URI | |||||||||||
関連識別子 | https://doors.doshisha.ac.jp/opac/opac_link/bibid/SB12902196/?lang=0 | |||||||||||
言語 | ja | |||||||||||
関連名称 | 掲載刊行物所蔵情報へのリンク / Link to Contents | |||||||||||
フォーマット | ||||||||||||
内容記述タイプ | Other | |||||||||||
内容記述 | application/pdf | |||||||||||
出版タイプ | ||||||||||||
出版タイプ | VoR | |||||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
日本十進分類法 | ||||||||||||
主題 | 492.89 |