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Changes in granulation-formation induced by different fiber-diameters and fiber-spacing in scaffolds for tissue-regeneration : preliminary study
https://doi.org/10.14988/pa.2017.0000012776
https://doi.org/10.14988/pa.2017.0000012776b3fb51d4-f22e-4662-9420-a24cdbfcc2d4
名前 / ファイル | ライセンス | アクション |
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023053010007.pdf (5.6 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||||||||||||||
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公開日 | 2012-06-12 | |||||||||||||||||
タイトル | ||||||||||||||||||
言語 | en | |||||||||||||||||
タイトル | Changes in granulation-formation induced by different fiber-diameters and fiber-spacing in scaffolds for tissue-regeneration : preliminary study | |||||||||||||||||
言語 | ||||||||||||||||||
言語 | eng | |||||||||||||||||
キーワード | ||||||||||||||||||
主題 | 細胞外マトリックス, 繊維径, 繊維間隔, 肉芽組織形成, 組織再生の足場 extracellular matrix, fiber-diameters, fiber-spacing, granulation-formation, scaffolds for tissue-regeneration |
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資源タイプ | ||||||||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
資源タイプ | departmental bulletin paper | |||||||||||||||||
ID登録 | ||||||||||||||||||
ID登録 | 10.14988/pa.2017.0000012776 | |||||||||||||||||
ID登録タイプ | JaLC | |||||||||||||||||
アクセス権 | ||||||||||||||||||
アクセス権 | open access | |||||||||||||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||||
その他(別言語等)のタイトル | ||||||||||||||||||
その他のタイトル | 組織再生足場の繊維径及び繊維間隔の違いが肉芽組織形成に及ぼす影響 | |||||||||||||||||
言語 | ja | |||||||||||||||||
その他(別言語等)のタイトル | ||||||||||||||||||
その他のタイトル | ソシキ サイセイ アシバ ノ センイケイ オヨビ センイ カンカク ノ チガイ ガ ニクゲ ソシキ ケイセイ ニ オヨボス エイキョウ | |||||||||||||||||
言語 | ja-Kana | |||||||||||||||||
著者 |
折笠, 太一
× 折笠, 太一× 池田, 潤基× 丹澤, あゆみ× 的場, 麻理× 岩目, 芳純× 吉田, 千子× 鳥井, 裕子× 小座本, 雄軌× 森田, 真一郎× 畠山, 紘一
WEKO
18427
× 中瀬, 有遠× 辻本, 洋行
WEKO
16525
× 萩原, 明郎 |
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著者所属(英) | ||||||||||||||||||
en | ||||||||||||||||||
Orikasa, Taichi / Undergraduate Senior, Department of Medical Life System, Doshisha University | ||||||||||||||||||
著者所属(英) | ||||||||||||||||||
en | ||||||||||||||||||
Ikeda, Junki / Undergraduate Senior, Department of Medical Life System, Doshisha University | ||||||||||||||||||
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Tanzawa, Ayumi / Undergraduate Senior, Department of Medical Life System, Doshisha University | ||||||||||||||||||
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Matoba, Mari / Undergraduate Senior, Department of Medical Life System, Doshisha University | ||||||||||||||||||
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Iwame, Yoshizumi / Undergraduate Senior, Department of Medical Life System, Doshisha University | ||||||||||||||||||
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Yoshida, Chiko / Undergraduate Sophomore, Department of Medical Life System, Doshisha University | ||||||||||||||||||
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Torii, Hiroko / Graduate Student, Department of Medical Life System, Doshisha University | ||||||||||||||||||
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Ozamoto, Yuki / Department of Kusatsu General Hospital | ||||||||||||||||||
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Morita, Shinichiro / Bio-Medical Material Research Center, Doshisha University | ||||||||||||||||||
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Hatakeyama, Koichi / Bio-Medical Material Research Center, Doshisha University | ||||||||||||||||||
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Nakase, Yuen / Department of Medical Life System, Doshisha University | ||||||||||||||||||
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Tsujimoto, Hiroyuki / Department of Medical Life System, Doshisha University | ||||||||||||||||||
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Hagiwara, Akeo / Department of Medical Life System, Doshisha University | ||||||||||||||||||
抄録 | ||||||||||||||||||
内容記述タイプ | Abstract | |||||||||||||||||
内容記述 | 目的:組織再生の足場は、直径が50~500nmである細胞外マトリックスの構造に可及的に類似することが望ましい。そこで、本実験では、直径0.7、0.9、3、7、20μmと繊維径の異なった5種類のポリグリコール酸繊維を用いて、5種類の不織布の足場を作製し、これらの足場が浸潤細胞及び肉芽組織形成に及ぼす影響を調べた。実験方法:6匹のラットの背部皮下組織に、それぞれ5つのポケットを作成し、5種類の足場を1つずつ別々のポケットに埋稙した。埋稙した足場とその周囲組織を、術後14日目に摘出し、病理組織学的に浸潤細胞及び肉芽組織形成の2つの観点から評価した。結果:繊維径0.9μmで繊維間隔10.8μmの足場と繊維径3μmで繊維間隔9.0μmの足場を用いた場合は、緻密な肉芽組織が足場の全層に渡り形成された。繊維径7μmで繊維間隔15.1μmの足場と繊維径20μmで繊維間隔31.6μmの足場を用いた場合は、疎な肉芽組織が繊維束間の空間に、やや疎な肉芽組織は、繊維束の周囲にのみ形成されていた。繊維径0.7μmで繊維間隔1.8μmの足場では、緻密な肉芽組織が足場の表面にのみ形成され、足場の内側へは細胞浸潤・肉芽組織形成は見られなかった。結論:繊維径3μm未満で繊維間隔が10μm付近の足場が、足場全層に渡り緻密な肉芽組織形成を引き起こし、組織再生の足場として最も適切であると考えられた。 | |||||||||||||||||
言語 | ja | |||||||||||||||||
抄録 | ||||||||||||||||||
内容記述タイプ | Abstract | |||||||||||||||||
内容記述 | The fibers of the extracellular matrix (ECM) typically have diameters ranging from 50 to 500 nm. A scaffold should mimic the structure of the ECM as much as possible. As a result, 5 different fibers with diameters of 0.7, 0.9, 3, 7 and 20 μm were made into 5 kinds of scaffolds for tissue-regeneration. The scaffolds were made of Poly(glycolic acid) (PGA) nonwoven fabrics with fiber-spacing of 1.8 to 31.6 μm. This study investigated the influence of the 5 different scaffolds on infiltrating cells and granulation-formation. Six female Wistar rats underwent surgery to create 5 “pockets" in the subcutaneous tissue of the back, and one of the 5 types of PGA scaffolds was implanted into each “pocket". These implanted PGA scaffolds and surrounding tissues were excised en block on postoperative days 14, and then the infiltrating cells and granulation-formation were assessed microscopically. In the scaffolds with a fiber-diameters of 0.9 and 3 μm and fiber-spacing of 10.8 and 9.0 μm, respectively, dense granulation tissue was formed over the full-thickness of the scaffolds. However, in the scaffolds with fiber-diameters of 7 and 20 μm and fiber-spacing of 15.1 and 31.6 μm, respectively, a relatively sparse granulation tissue was formed only around the fiber bundles and sparse granulation tissue was observed to form in the spaces between the bundles. In the scaffolds with a fiber-diameter of 0.7 and fiber-spacing of 1.8 μm, dense granulation tissue only formed in the superficial and shallow layers of the scaffolds, and no cell-infiltration was found in the central region of the thickness. These results suggest that scaffolds with fiber-diameters smaller than 3 μm and fiber-spacing approximately 10 μm are suitable for artificial scaffolds made with PGA fibers to induce the regeneration of dense granulation tissue over the full-thickness of the scaffold. | |||||||||||||||||
言語 | en | |||||||||||||||||
書誌情報 |
ja : 同志社大学理工学研究報告 en : The Science and Engineering Review of Doshisha University 巻 53, 号 1, p. 42-48, 発行日 2012-04-30 |
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言語 | ja | |||||||||||||||||
出版者 | 同志社大学理工学研究所 | |||||||||||||||||
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言語 | en | |||||||||||||||||
出版者 | Science and Engineering Research Institute of Doshisha University | |||||||||||||||||
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収録物識別子タイプ | PISSN | |||||||||||||||||
収録物識別子 | 00368172 | |||||||||||||||||
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収録物識別子タイプ | NCID | |||||||||||||||||
収録物識別子 | AN00165868 | |||||||||||||||||
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権利者名 | 同志社大学理工学研究所 | |||||||||||||||||
言語 | ja | |||||||||||||||||
権利者名 | Science and Engineering Research Institute of Doshisha University | |||||||||||||||||
言語 | en | |||||||||||||||||
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関連タイプ | isFormatOf | |||||||||||||||||
識別子タイプ | URI | |||||||||||||||||
関連識別子 | https://doors.doshisha.ac.jp/opac/opac_link/bibid/SB00960326/?lang=0 | |||||||||||||||||
言語 | ja | |||||||||||||||||
関連名称 | 掲載刊行物所蔵情報へのリンク / Link to Contents | |||||||||||||||||
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内容記述タイプ | Other | |||||||||||||||||
内容記述 | application/pdf | |||||||||||||||||
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出版タイプ | VoR | |||||||||||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||
日本十進分類法 | ||||||||||||||||||
主題 | 491.11 |