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Distinct modes of endocytotic presynaptic membrane and protein retrieval at the calyx of held terminal
https://doi.org/10.14988/di.2018.0000000339
https://doi.org/10.14988/di.2018.0000000339d4f3cbb6-1427-43f9-8148-221f5420772b
名前 / ファイル | ライセンス | アクション |
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要旨/abstaract (274.3 kB)
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zk950.pdf (2.5 MB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2018-05-11 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Distinct modes of endocytotic presynaptic membrane and protein retrieval at the calyx of held terminal | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題 | synapse, presynaptic, terminal, synaptic vesicle, endocytosis, calyx of Held, capacitance measurements, imaging | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
ID登録 | ||||||
ID登録 | 10.14988/di.2018.0000000339 | |||||
ID登録タイプ | JaLC | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
その他(別言語等)のタイトル | ||||||
その他のタイトル | カリックス型シナプス前終末におけるシナプス小胞膜および小胞タンパク質の取り込み機構の研究 | |||||
言語 | ja | |||||
その他(別言語等)のタイトル | ||||||
その他のタイトル | カリックスガタ シナプス ゼンシュウマツ ニオケル シナプス ショウホウマク オヨビ ショウホウ タンパクシツ ノ トリコミ キコウ ノ ケンキュウ | |||||
言語 | ja-Kana | |||||
著者 |
岡本, 悠志
× 岡本, 悠志 |
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著者所属 | ||||||
ja | ||||||
脳科学研究科 | ||||||
著者所属(英) | ||||||
en | ||||||
Graduate School of Brain Science | ||||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 化学シナプスにおいて、シナプス小胞内に蓄えられた神経伝達物質の開口放出によってシナプス伝達が起こる。開口放出後、シナプス小胞はエンドサイトーシスによって細胞内へ回収されて再利用される。膜容量測定法とpHイメージングを併用して、開口放出とエンドサイトーシスに伴う小胞膜および小胞タンパク質の動態を同時測定した。Ca2+-カルモジュリン-Munc13シグナリングが小胞タンパク質の回収に関与していることが示唆された。 | |||||
言語 | ja | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Neurotransmitter is released at synapses by fusion of synaptic vesicles with the plasma membrane. To sustain synaptic transmission, membranes and vesicular proteins has to be retrieved for reuse. I have combined capacitance measurements and pH-imaging via a pH-sensitive vesicular protein marker, and compared the retrieval kinetics of membranes and synaptotagmin2 (Syt2) at the calyx of Held presynaptic terminal. Data in this thesis identifies a novel mechanism of stimulus- and Ca2+-dependent regulation of coordinated endocytosis of synaptic membranes and Syt2. | |||||
言語 | en | |||||
書誌レコードID | ||||||
識別子タイプ | NCID | |||||
関連識別子 | BB26653634 | |||||
関連サイト | ||||||
関連タイプ | isFormatOf | |||||
識別子タイプ | URI | |||||
関連識別子 | https://doors.doshisha.ac.jp/opac/opac_link/bibid/BB13060320/?lang=0 | |||||
言語 | ja | |||||
関連名称 | 掲載刊行物所蔵情報へのリンク / Link to Contents | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
学位名 | ||||||
言語 | ja | |||||
学位名 | 博士(理学) | |||||
学位名(英) | ||||||
言語 | en | |||||
学位名 | Doctor of Philosophy in Science | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 34310 | |||||
言語 | ja | |||||
学位授与機関名 | 同志社大学 | |||||
言語 | en | |||||
学位授与機関名 | Doshisha University | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2018-03-22 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲第950号 |