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Critical role of Ca2+ current facilitation in the short-term facilitation of Purkinje cell-Purkinje cell synapses
https://doi.org/10.14988/di.2017.0000016319
https://doi.org/10.14988/di.2017.00000163191816774c-9f0e-4c3d-8f53-dd2f5fdbd562
名前 / ファイル | ライセンス | アクション |
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要旨/abstaract (402.4 kB)
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zk797.pdf (2.0 MB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2016-07-01 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Critical role of Ca2+ current facilitation in the short-term facilitation of Purkinje cell-Purkinje cell synapses | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題 | Synapse, Short-term facilitation, Synaptic plasticity, Purkinje cell | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
ID登録 | ||||||
ID登録 | 10.14988/di.2017.0000016319 | |||||
ID登録タイプ | JaLC | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
その他(別言語等)のタイトル | ||||||
その他のタイトル | プルキンエ細胞間シナプス短期促通現象におけるCa電流の役割 | |||||
言語 | ja | |||||
その他(別言語等)のタイトル | ||||||
その他のタイトル | プリキンエ サイボウカン シナプス タンキ ソクツウ ゲンショウ ニオケル Ca デンリュウ ノ ヤクワリ | |||||
言語 | ja-Kana | |||||
著者 |
Díaz-Rojas, Françoise
× Díaz-Rojas, Françoise |
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著者所属 | ||||||
ja | ||||||
脳科学研究科 | ||||||
著者所属(英) | ||||||
en | ||||||
Graduate School of Brain Science | ||||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Short-term facilitation, a form of synaptic plasticity, takes place at GABAergic synapses between cerebellar Purkinje cells (PCs). We studied the mechanism of this short-term facilitation by directly patch-clamp recording from a PC axon terminal in cerebellar cultures. We show that the Ca2+ currents elicited by high-frequency action potentials were augmented depending on intracellular [Ca2+] on the terminal. The facilitation of synaptic transmission showed 4-5th power dependence on the Ca2+ current facilitation, and was abolished when the Ca2+ current facilitation was supressed. We conclude that short-term facilitation of Ca2+ currents predominantly mediates short-term facilitation at synapses between PCs. | |||||
言語 | en | |||||
書誌レコードID | ||||||
識別子タイプ | NCID | |||||
関連識別子 | BB23382803 | |||||
関連サイト | ||||||
関連タイプ | isFormatOf | |||||
識別子タイプ | URI | |||||
関連識別子 | https://doors.doshisha.ac.jp/opac/opac_link/bibid/BB12998786/?lang=0 | |||||
言語 | ja | |||||
関連名称 | 掲載刊行物所蔵情報へのリンク / Link to Contents | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
学位名 | ||||||
言語 | ja | |||||
学位名 | 博士(理学) | |||||
学位名(英) | ||||||
言語 | en | |||||
学位名 | Doctor of Philosophy in Science | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 34310 | |||||
言語 | ja | |||||
学位授与機関名 | 同志社大学 | |||||
言語 | en | |||||
学位授与機関名 | Doshisha University | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2016-03-22 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲第797号 |