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HME was produced using hot water extraction from Anthemis nobilis (Roman chamomile), Crataegus oxyacantha (hawthorn berry), Houttuynia cordata (dokudami), and Vitis vinifera (grape leaf). MHE can be regarded as a Chinese herbal remedy. In Chinese herbal remedy, it is well known that a little of additional crude drugs can change the original effects. We assessed whether a capsulated novel remedy of MHE with Zingiber officinale (syouga) and Zanthoxylum piperitum (sansho) showed an anti-glycation effect. We also assessed its effects on one\u0027s quality of life (QOL). The subjects consisted of 12 volunteers divided into two groups, the Normal Blood Sugar (NBS) Group (male: 1; female: 7; age: 47.3 ± 10.2 years) and the Diabetes Mellitus / Impaired Fasting Glycaemia (DM/IFG) Group (male: 3; female: 1; age: 51.5 ± 12.7 years) with HbA1c 5.7~7.0. 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Stopping the intake at 12 weeks resulted in a deterioration of skin AF. The skin elasticity index R2 in the DM/IFG Group showed a slight improving tendency after 12 weeks. The novel remedy of MHE with additional two crude drugs inhibited the accumulation of AGEs in the skin. 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混合ハーブ抽出物と2つの生薬からなる新規ハーブ混合物の抗糖化作用 : 短期および長期の影響
https://doi.org/10.14988/pa.2017.0000012597
https://doi.org/10.14988/pa.2017.000001259709ca60f8-6af6-4f97-805e-502f38b56bf4
名前 / ファイル | ライセンス | アクション |
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023052040003.pdf (6.7 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||||||||
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公開日 | 2012-02-23 | |||||||||||
タイトル | ||||||||||||
言語 | ja | |||||||||||
タイトル | 混合ハーブ抽出物と2つの生薬からなる新規ハーブ混合物の抗糖化作用 : 短期および長期の影響 | |||||||||||
タイトル | ||||||||||||
言語 | ja-Kana | |||||||||||
タイトル | コンゴウ ハーブ チュウシュツブツ ト 2ツ ノ ショウヤク カラ ナル シンキ ハーブ コンゴウブツ ノ コウトウカ サヨウ : タンキ オヨビ チョウキ ノ エイキョウ | |||||||||||
タイトル | ||||||||||||
言語 | en | |||||||||||
タイトル | Anti-glycation effect of a novel herbal mixture made of mixed herbal extract and two crude drugs : short and long term effect | |||||||||||
言語 | ||||||||||||
言語 | jpn | |||||||||||
キーワード | ||||||||||||
主題 | メイラード反応, 最終糖化生成物, 抗糖化, 混合ハーブ抽出物, 生薬 Maillard reaction, advanced glycation endproducts, anti-glycation, mixed herbal extract, crude drug |
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資源タイプ | ||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
資源タイプ | departmental bulletin paper | |||||||||||
ID登録 | ||||||||||||
ID登録 | 10.14988/pa.2017.0000012597 | |||||||||||
ID登録タイプ | JaLC | |||||||||||
アクセス権 | ||||||||||||
アクセス権 | open access | |||||||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
著者 |
田村, 隆朗
× 田村, 隆朗× 八木, 雅之× 埜本, 慶太郎× 米井, 嘉一
WEKO
17121
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著者所属 | ||||||||||||
ja | ||||||||||||
田村, 隆朗 / Tamura Clinic | ||||||||||||
著者所属 | ||||||||||||
ja | ||||||||||||
八木, 雅之 / 同志社大学生命医科学部チェアプロフェッサー講師 | ||||||||||||
著者所属 | ||||||||||||
ja | ||||||||||||
埜本, 慶太郎 / Anti-Aging Medical Research Center and Glycation Stress Research Center, Graduate School of Life and Medical Sciences, Doshisha University | ||||||||||||
著者所属 | ||||||||||||
ja | ||||||||||||
米井, 嘉一 / 同志社大学生命医科学部医生命システム学科教授 | ||||||||||||
抄録 | ||||||||||||
内容記述タイプ | Abstract | |||||||||||
内容記述 | 混合ハーブ抽出物 (MHE)は抗糖化作用が既に報告されている。HMEはローマカミツレ・セイヨウサンザシ・ドクダミ・ブドウ葉の熱水抽出物である。HMEは漢方薬とみなすことができる。漢方薬では、構成生薬の追加が元の効能を変化させることが知られている。HMEに生薬である生姜・山椒を加えカプセルに充填した試験食を作成し、それが抗糖化作用を示すか調べた。またQOLへの影響を調べた。対象者は12名で、血糖正常群8名(男:女1:7、平均年齢47歳)と糖尿病・高血糖群4名(男:女3:1、平均年齢51歳、HbA1c 5.7~7.0)の2群に分けられた。両群とも、HMEはエキス固形分240mgと生姜・山椒一定量を1日量として4カプセル・12週間摂取した。また各群の1名ずつは80週間摂取を継続した。抗糖化作用は皮膚AGEs蓄積を非侵襲的に測定し皮膚自発蛍光(AF)として示すAGE reader™により評価した。皮膚弾力はCutometerにより評価した。 抗加齢QOL共通問診表により「便秘」、「冷え性」、「体重減少」が有意(p=0.043)の改善または変化を認めた。皮膚AFは8週・12週にて両群とも減少し、血糖正常群では12週で有意(p=0.020)な低下を認めた。80週までの継続摂取では皮膚AF減少は継続した。12週での摂取終了は皮膚AFの悪化を認めた。皮膚弾力は糖尿病・高血糖群の12週でR2に若干の改善を認めた。MHEに2つの生薬を追加配合した処方は皮膚AGEs蓄積を抑制した。試験食の継続摂取は安全で有用な抗糖化法と考えられることが示唆された。 | |||||||||||
言語 | ja | |||||||||||
抄録 | ||||||||||||
内容記述タイプ | Abstract | |||||||||||
内容記述 | The anti-glycation effect of mixed herbal extract (MHE) was already reported. HME was produced using hot water extraction from Anthemis nobilis (Roman chamomile), Crataegus oxyacantha (hawthorn berry), Houttuynia cordata (dokudami), and Vitis vinifera (grape leaf). MHE can be regarded as a Chinese herbal remedy. In Chinese herbal remedy, it is well known that a little of additional crude drugs can change the original effects. We assessed whether a capsulated novel remedy of MHE with Zingiber officinale (syouga) and Zanthoxylum piperitum (sansho) showed an anti-glycation effect. We also assessed its effects on one's quality of life (QOL). The subjects consisted of 12 volunteers divided into two groups, the Normal Blood Sugar (NBS) Group (male: 1; female: 7; age: 47.3 ± 10.2 years) and the Diabetes Mellitus / Impaired Fasting Glycaemia (DM/IFG) Group (male: 3; female: 1; age: 51.5 ± 12.7 years) with HbA1c 5.7~7.0. Both of the Groups were administered 240 mg of MHE (solid substance) with certain amounts of Zingiber officinale (syouga) and Zanthoxylum piperitum (sansyo) in 4 capsules per day for 12 weeks. Two individuals - one of NBS Group and the other of DM/IFG Group - were administered continuously for 80 weeks. The inhibition of glycation was assessed by AGE reader™, non-invasively measuring the advanced glycation endproducts (AGEs) as skin auto fluorescence (AF). Also the skin elasticity was assessed by Cutometer. The analysis using the Anti-Aging QOL Common Questionnaire (AAQol) showed that the score for the parameters, “constipation", “cold skin", and “weight loss; thin" were significantly improved or changed (p=0.043). The skin AF decreased in the both Groups after 8 and 12 weeks respectively, and significant variation (p=0.020) was observed in the NBS Group after 12 weeks. Continuous intake for 80 weeks revealed continuing low values of skin AF. Stopping the intake at 12 weeks resulted in a deterioration of skin AF. The skin elasticity index R2 in the DM/IFG Group showed a slight improving tendency after 12 weeks. The novel remedy of MHE with additional two crude drugs inhibited the accumulation of AGEs in the skin. These results suggest that a continuous supplementation of the test product was considered to be a safe anti-glycation method. | |||||||||||
言語 | en | |||||||||||
書誌情報 |
ja : 同志社大学理工学研究報告 en : The Science and Engineering Review of Doshisha University 巻 52, 号 4, p. 244-252, 発行日 2012-01-31 |
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出版者 | ||||||||||||
言語 | ja | |||||||||||
出版者 | 同志社大学理工学研究所 | |||||||||||
出版者(英) | ||||||||||||
言語 | en | |||||||||||
出版者 | Science and Engineering Research Institute of Doshisha University | |||||||||||
ISSN | ||||||||||||
収録物識別子タイプ | PISSN | |||||||||||
収録物識別子 | 00368172 | |||||||||||
書誌レコードID | ||||||||||||
収録物識別子タイプ | NCID | |||||||||||
収録物識別子 | AN00165868 | |||||||||||
権利者情報 | ||||||||||||
権利者名 | 同志社大学理工学研究所 | |||||||||||
言語 | ja | |||||||||||
権利者名 | Science and Engineering Research Institute of Doshisha University | |||||||||||
言語 | en | |||||||||||
関連サイト | ||||||||||||
関連タイプ | isFormatOf | |||||||||||
識別子タイプ | URI | |||||||||||
関連識別子 | https://doors.doshisha.ac.jp/opac/opac_link/bibid/SB00960326/?lang=0 | |||||||||||
言語 | ja | |||||||||||
関連名称 | 掲載刊行物所蔵情報へのリンク / Link to Contents | |||||||||||
フォーマット | ||||||||||||
内容記述タイプ | Other | |||||||||||
内容記述 | application/pdf | |||||||||||
出版タイプ | ||||||||||||
出版タイプ | VoR | |||||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
日本十進分類法 | ||||||||||||
主題 | 464.3 |